Table 1 Minimum Inhibitory Concentrations of the idenfies Antimicrobial Peptides against a range of bacterial pathogens (μg/mL) (highest concentration tested = 512 μg/mL) ‘-’ not tested. OXA Oxacillin, IMI (imipenem), MER (meropenem)
From: The rumen eukaryotome is a source of novel antimicrobial peptides with therapeutic potential
Peptide ID | S. aureus MSSA | S. aureus USA300 | S. aureus ATCC 33591 | S. aureus EMRSA-15 | Ent. faecalis | B. cereus | E. coli K12 | Sal. Tyhimurium | P. aeruginosa PAO1 | P. aeruginosa H174 | A. baumannii DSMZ 30007 | A. baumannii S27379 Sen | A. baumannii S15785 OXA-23/0XA-50 | A. baumannii IMI/MER-R |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lub_323 | 512 | > 512 | > 512 | > 512 | 512 | > 512 | 512 | 512 | 512 | 512 | 512 | 512 | 512 | 512 |
Lub_353 | 256 | 256 | 256 | > 512 | 256 | 512 | 128 | 256 | 256 | 512 | 256 | 256 | 512 | 128 |
Lub_364 | > 512 | > 512 | > 512 | > 512 | 256 | > 512 | 256 | > 512 | > 512 | > 512 | 256 | 256 | 512 | 256 |
Lub_376 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 |
Lubelisin (Lub_383) | 8 | 8 | 8 | 8 | 16 | 64 | 64 | 128 | 128 | 256 | 128 | 32 | 128 | 128 |
Lub_405 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 |
Lub_424 | > 512 | > 512 | > 512 | > 512 | 512 | > 512 | 256 | 512 | > 512 | 512 | > 512 | > 512 | 512 | > 512 |
Lub_443 | 512 | 256 | > 512 | 256 | 256 | 512 | 256 | > 512 | > 512 | > 512 | 512 | 256 | 256 | 256 |
Lub_444 | 256 | 256 | 256 | 128 | 128 | > 512 | 256 | > 512 | > 512 | 512 | 512 | 256 | 512 | 512 |
Lub_454 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 |
Lub_458 | > 512 | > 512 | > 512 | > 512 | 512 | > 512 | 512 | > 512 | > 512 | > 512 | 512 | 512 | 512 | 512 |
Lub_523 | 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | 512 | > 512 | 512 |
Lub_526 | > 512 | > 512 | 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 | > 512 |
Vancomycin | 2 | 2 | 2 | 2 | 2 | 2 | – | – | – | – | – | – | – | – |
Levofloxacin | – | – | – | – | – | – | 0.03 | 0.12 | 0.06 | 0.5 | 0.25 | 0.12 | > 512 | 256 |
Polymyxin B | – | – | – | – | – | – | 0.5 | 1 | 2 | 1 | 1 | 1 | 0.5 | 1 |