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Fig. 1 | BMC Microbiology

Fig. 1

From: Defining the temporal evolution of gut dysbiosis and inflammatory responses leading to hepatocellular carcinoma in Mdr2 −/− mouse model

Fig. 1

Multidrug resistant 2 knock out (Mdr2 −/−) mice: a model of inflammation mediated hepatocarcinogenesis. a Diagram showing time points of sample collection (stool, blood and liver tissue) of Mdr2−/− mice and respective wild type (WT) mice. Samples were collected from Mdr2−/− mice at time points reflecting liver inflammation/Mdr2−/− (12 weeks, n = 6), liver cirrhosis/Mdr2−/− (21 weeks, n = 9) and hepatocellular carcinoma (HCC)/Mdr2−/− (42 weeks, n = 10) after birth. Samples were collected from WT mice at 12 weeks (baseline/WT, n = 6) and 42 weeks (aged/WT, n = 6) after birth to control for effect of ageing. b Representative macroscopic images and histology of liver tissue from WT mice at 12 weeks (baseline/WT, n = 6), and Mdr2 −/− mice at 12 weeks (inflammation/Mdr2−/−, n = 6), 21 weeks (cirrhosis/Mdr2−/−, n = 9) and 42 weeks (HCC/Mdr2−/−, n = 10) timepoints, stained with Hematoxylin & Eosin, Reticulin and Masson’s Trichrome. Macroscopic images are to scale on background grid (10 mm × 10 mm) and histology taken at 20x magnification. Panel (a) was created with Biorender.com

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