Fig. 5

Time-dependent changes in the numbers of RNA-binding motif loci. a The numbers of loci containing RNA-binding motifs per genome are plotted against the elapsed month. Here, we selected RNA-binding proteins for which the number of motif loci increased or decreased by at least one for all six clades from the epidemic start. The data are presented as colored or dashed lines, as described in Fig. 1a. b A boxplot shows the number of loci containing RNA-binding motifs in human-CoV (alpha 229E and NL63: beta HKU1 and OC43), bat-CoV (bat SARS, alphacoronavirus and betacoronavirus) and SARS-CoV-2 strains. Bat SARS are marked pink. A hallow arrow indicates the direction shown in Fig. 5a with which the oligonucleotide compositions of SARS-CoV-2 changed