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Table 1 Demographics of participants

From: Distinction between vaginal and cervical microbiota in high-risk human papilloma virus-infected women in China

 

Normal

(n = 20)

Other hrHPV(+)

(n = 32)

HPV16/18(+)

(n = 38)

Cervical cancer

(n = 10)

P*

Mean age (years)

38.35 ± 3.72

36.75 ± 6.15

35.73 ± 6.89

38.80 ± 3.08

0.289

TCT

 Normal

20

9 (28.1%)

22 (57.9%)

-a

 

 Ascus

11 (34.3%)

3 (7.9%)

 

 LSIL

8 (25.0%)

4 (10.5%)

 

 HSIL

2 (6.3%)

7 (18.4%)

 

 ASC-H

2 (6.3%)

2 (5.3%)

 

HPV subtypesb

 16

31 (81.6%)

8 (80.0%)

 

 18

8 (47.4%)

3 (30.0%)

 

 16and18

1 (2.6%)

1 (10.0%)

 

 31

1 (3.1%)

1 (2.6%)

0

 

 33

4 (12.5%)

2 (5.3%)

0

 

 35

1 (3.1%)

0

1 (10.0%)

 

 51

2 (6.3%)

3 (7.9%)

0

 

 52

12 (37.5%)

3 (7.9%)

0

 

 53

4 (12.5%)

2 (5.3%)

0

 

 56

3 (9.4%)

2 (5.3%)

0

 

 58

5 (15.6%)

2 (5.3%)

0

 

 59

3 (9.4%)

0

0

 

 66

2 (6.3%)

0

0

 

 68

3 (9.4%)

0

0

 

Vaginitis or not

    

0.002

 Normal

16 (80.0%)

27 (84.4%)

25 (65.8%)

3 (30.0%)

 

 Bacterial vaginosis

2 (10.0%)

5 (15.6%)

13 (34.2%)

5 (50.0%)

 

 Abnormal flora

1 (5.0%)

0

0

1 (10.0%)

 

 Flora suppression

1 (5.0%)

0

0

1 (10.0%)

 

Leukocytes at cervix

    

0.001

 0–10

14 (70.0%)

12 (37.5%)

12 (31.6%)

1 (10.0%)

 

 >10

6 (30.0%)

20 (62.5%)

26 (68.4%)

9 (90.0%)

 

Cervical biopsy

    

0.129

 Normal

20

0

0

 

 Cervicitis

14 (43.8%)

11 (28.9%)

 

 LSIL

11 (34.4%)

10 (26.3%)

 

 HSIL

7 (21.8%)

17 (44.8%)

 

 Cancer

0

10

10

 

Educational level

    

0.478

 <Bachelor

9 (45.0%)

12 (37.5%)

17 (44.7%)

5 (50.0%)

 

 Bachelor

10 (50.0%)

19 (59.4%)

15 (39.5%)

5 (50.0%)

 

  ≥ Master

1 (5.0%)

1 (3.1%)

6 (15.8%)

0

 

Monthly income (¥)

    

0.295

 <5000

8 (40.0%)

9 (28.1%)

19 (50.0%)

6 (60.0%)

 

 5000–10,000

10 (50.0%)

17 (53.1%)

12 (31.6%)

4 (40.0%)

 

 >10,000

2 (10.0%)

6 (18.8%)

7 (18.4%)

0

 

Occupation

    

0.838

 Medical service

2 (10.0%)

2 (6.3%)

0

0

 

 Economics

2 (10.0%)

5 (15.6%)

5 (13.2%)

0

 

 Education

1 (5.0%)

2 (6.3%)

4 (10.5%)

1 (10.0%)

 

 Art

1 (5.0%)

1 (3.1%)

1 (2.6%)

0

 

 Worker/Farmer

14 (70.0%)

22 (68.7%)

28 (73.7%)

9 (90.0%)

 

Frequency of cleaning vulva

    

0.306

 <1 time per week

0

4 (12.5%)

3 (7.9%)

0

 

 2–3 times per week

6 (30.0%)

5 (15.6%)

10 (26.3%)

5 (50.0%)

 

 Everyday

14 (70.0%)

23 (71.9%)

25 (65.8%)

5 (50.0%)

 

Way of cleaning vulva

    

0.195

 Clean water

19 (95.0%)

23 (71.9%)

31 (81.6%)

9 (90.0%)

 

 Lotion

1 (5.0%)

9 (28.1%)

7 (18.4%)

1 (10.0%)

 

History of vaginal douching

    

0.001

 Yes

0

11 (34.4%)

19 (50.0%)

4 (40.0%)

 

 No

20 (100.0%)

21 (65.6%)

19 (50.0%)

6 (60.0%)

 

Days of using sanitary pads

    

0.007

  ≥ 10 days per month

2 (10.0%)

10 (31.3%)

9 (23.7%)

7 (70.0%)

 

 <10 days per month

18 (90.0%)

22 (68.7%)

29 (76.3%)

3 (30.0%)

 

Smoking or not

    

0.710

 Yes

0

2 (6.3%)

1 (2.6%)

0

 

 No

20 (100.0%)

30 (93.7%)

37 (97.4%)

10 (100.0%)

 

Age of first sex

    

0.152

 <20 years old

1 (5.0%)

9 (28.1%)

5 (13.2%)

1 (10.0%)

 

  ≥ 20 years old

19 (95.0%)

23 (71.9%)

32 (86.8%)

9 (90.0%)

 

Number of sex partner

    

0.047

 1

18 (90.0%)

15 (46.8%)

21 (55.3%)

7 (70.0%)

 

 2

2 (10.0%)

11 (34.4%)

13 (34.2%)

3 (30.0%)

 

  ≥ 3

0

6 (18.8%)

4 (10.5%)

0

 

Frequency of sex

    

0.025

 < 1 time per week

16 (80.0%)

20 (62.5%)

20 (52.7%)

2 (20.0%)

 

 2–3 times per week

4 (20.0%)

9 (28.1%)

14 (36.8%)

8 (80.0%)

 

  ≥ 3 times per week

0

3 (9.4%)

4 (10.5%)

0

 

Methods of contraceptionc

    

0.001

 None

2 (10.0%)

2 (6.3%)

5 (13.2%)

2 (20.0%)

 

 Condom

15 (75.0%)

12 (37.5%)

13 (34.2%)

1 (10.0%)

 

 Oral contraceptive

0

1 (3.1%)

2 (5.3%)

0

 

 Intrauterine device

3 (15.0%)

3 (9.4%)

6 (15.8%)

5 (50.0%)

 

 Others

0

14 (43.7%)

12 (31.6%)

2 (20.0%)

 

Parity

    

0.955

  ≤ 1 time

18 (90.0%)

30 (93.8%)

35 (92.1%)

9 (90.0%)

 

  ≥ 2 times

2 (10.0%)

2 (6.2%)

3 (7.9%)

1 (10.0%)

 

Number of abortion

    

0.222

  ≤ 1 time

12 (60.0%)

27 (84.4%)

30 (78.9%)

7 (70.0%)

 

  ≥ 2 times

8 (40.0%)

5 (15.6%)

8 (21.1%)

3 (30.0%)

 

History of vaginitis

    

0.002

 Yes

2 (10.0%)

14 (43.7%)

21 (55.3%)

7 (70.0%)

 

 No

18 (90.0%)

18 (56.3%)

17 (44.7)

3 (30.0%)

 
  1. Abbreviations: hrHPV high-risk human papilloma virus, TCT thin-prep cytology test, Ascus atypical squamous cell of undetermined significance, LSIL low-grade squamous intraepithelial lesion, HSIL high-grade squamous intraepithelial lesion, ASC-H atypical squamous cell- cannot exclude HSIL
  2. *: P values were calculated by ANOVA, Chi-square test or Fisher exact probability test
  3. a: “-” means no sense; b: HPV subtypes might overlap in each participant; c: Methods of contraception means the most common way of birth control