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Table 1 Demographics of participants

From: Distinction between vaginal and cervical microbiota in high-risk human papilloma virus-infected women in China

  Normal
(n = 20)
Other hrHPV(+)
(n = 32)
HPV16/18(+)
(n = 38)
Cervical cancer
(n = 10)
P*
Mean age (years) 38.35 ± 3.72 36.75 ± 6.15 35.73 ± 6.89 38.80 ± 3.08 0.289
TCT
 Normal 20 9 (28.1%) 22 (57.9%) -a  
 Ascus 11 (34.3%) 3 (7.9%)  
 LSIL 8 (25.0%) 4 (10.5%)  
 HSIL 2 (6.3%) 7 (18.4%)  
 ASC-H 2 (6.3%) 2 (5.3%)  
HPV subtypesb
 16 31 (81.6%) 8 (80.0%)  
 18 8 (47.4%) 3 (30.0%)  
 16and18 1 (2.6%) 1 (10.0%)  
 31 1 (3.1%) 1 (2.6%) 0  
 33 4 (12.5%) 2 (5.3%) 0  
 35 1 (3.1%) 0 1 (10.0%)  
 51 2 (6.3%) 3 (7.9%) 0  
 52 12 (37.5%) 3 (7.9%) 0  
 53 4 (12.5%) 2 (5.3%) 0  
 56 3 (9.4%) 2 (5.3%) 0  
 58 5 (15.6%) 2 (5.3%) 0  
 59 3 (9.4%) 0 0  
 66 2 (6.3%) 0 0  
 68 3 (9.4%) 0 0  
Vaginitis or not      0.002
 Normal 16 (80.0%) 27 (84.4%) 25 (65.8%) 3 (30.0%)  
 Bacterial vaginosis 2 (10.0%) 5 (15.6%) 13 (34.2%) 5 (50.0%)  
 Abnormal flora 1 (5.0%) 0 0 1 (10.0%)  
 Flora suppression 1 (5.0%) 0 0 1 (10.0%)  
Leukocytes at cervix      0.001
 0–10 14 (70.0%) 12 (37.5%) 12 (31.6%) 1 (10.0%)  
 >10 6 (30.0%) 20 (62.5%) 26 (68.4%) 9 (90.0%)  
Cervical biopsy      0.129
 Normal 20 0 0  
 Cervicitis 14 (43.8%) 11 (28.9%)  
 LSIL 11 (34.4%) 10 (26.3%)  
 HSIL 7 (21.8%) 17 (44.8%)  
 Cancer 0 10 10  
Educational level      0.478
 <Bachelor 9 (45.0%) 12 (37.5%) 17 (44.7%) 5 (50.0%)  
 Bachelor 10 (50.0%) 19 (59.4%) 15 (39.5%) 5 (50.0%)  
  ≥ Master 1 (5.0%) 1 (3.1%) 6 (15.8%) 0  
Monthly income (¥)      0.295
 <5000 8 (40.0%) 9 (28.1%) 19 (50.0%) 6 (60.0%)  
 5000–10,000 10 (50.0%) 17 (53.1%) 12 (31.6%) 4 (40.0%)  
 >10,000 2 (10.0%) 6 (18.8%) 7 (18.4%) 0  
Occupation      0.838
 Medical service 2 (10.0%) 2 (6.3%) 0 0  
 Economics 2 (10.0%) 5 (15.6%) 5 (13.2%) 0  
 Education 1 (5.0%) 2 (6.3%) 4 (10.5%) 1 (10.0%)  
 Art 1 (5.0%) 1 (3.1%) 1 (2.6%) 0  
 Worker/Farmer 14 (70.0%) 22 (68.7%) 28 (73.7%) 9 (90.0%)  
Frequency of cleaning vulva      0.306
 <1 time per week 0 4 (12.5%) 3 (7.9%) 0  
 2–3 times per week 6 (30.0%) 5 (15.6%) 10 (26.3%) 5 (50.0%)  
 Everyday 14 (70.0%) 23 (71.9%) 25 (65.8%) 5 (50.0%)  
Way of cleaning vulva      0.195
 Clean water 19 (95.0%) 23 (71.9%) 31 (81.6%) 9 (90.0%)  
 Lotion 1 (5.0%) 9 (28.1%) 7 (18.4%) 1 (10.0%)  
History of vaginal douching      0.001
 Yes 0 11 (34.4%) 19 (50.0%) 4 (40.0%)  
 No 20 (100.0%) 21 (65.6%) 19 (50.0%) 6 (60.0%)  
Days of using sanitary pads      0.007
  ≥ 10 days per month 2 (10.0%) 10 (31.3%) 9 (23.7%) 7 (70.0%)  
 <10 days per month 18 (90.0%) 22 (68.7%) 29 (76.3%) 3 (30.0%)  
Smoking or not      0.710
 Yes 0 2 (6.3%) 1 (2.6%) 0  
 No 20 (100.0%) 30 (93.7%) 37 (97.4%) 10 (100.0%)  
Age of first sex      0.152
 <20 years old 1 (5.0%) 9 (28.1%) 5 (13.2%) 1 (10.0%)  
  ≥ 20 years old 19 (95.0%) 23 (71.9%) 32 (86.8%) 9 (90.0%)  
Number of sex partner      0.047
 1 18 (90.0%) 15 (46.8%) 21 (55.3%) 7 (70.0%)  
 2 2 (10.0%) 11 (34.4%) 13 (34.2%) 3 (30.0%)  
  ≥ 3 0 6 (18.8%) 4 (10.5%) 0  
Frequency of sex      0.025
 < 1 time per week 16 (80.0%) 20 (62.5%) 20 (52.7%) 2 (20.0%)  
 2–3 times per week 4 (20.0%) 9 (28.1%) 14 (36.8%) 8 (80.0%)  
  ≥ 3 times per week 0 3 (9.4%) 4 (10.5%) 0  
Methods of contraceptionc      0.001
 None 2 (10.0%) 2 (6.3%) 5 (13.2%) 2 (20.0%)  
 Condom 15 (75.0%) 12 (37.5%) 13 (34.2%) 1 (10.0%)  
 Oral contraceptive 0 1 (3.1%) 2 (5.3%) 0  
 Intrauterine device 3 (15.0%) 3 (9.4%) 6 (15.8%) 5 (50.0%)  
 Others 0 14 (43.7%) 12 (31.6%) 2 (20.0%)  
Parity      0.955
  ≤ 1 time 18 (90.0%) 30 (93.8%) 35 (92.1%) 9 (90.0%)  
  ≥ 2 times 2 (10.0%) 2 (6.2%) 3 (7.9%) 1 (10.0%)  
Number of abortion      0.222
  ≤ 1 time 12 (60.0%) 27 (84.4%) 30 (78.9%) 7 (70.0%)  
  ≥ 2 times 8 (40.0%) 5 (15.6%) 8 (21.1%) 3 (30.0%)  
History of vaginitis      0.002
 Yes 2 (10.0%) 14 (43.7%) 21 (55.3%) 7 (70.0%)  
 No 18 (90.0%) 18 (56.3%) 17 (44.7) 3 (30.0%)  
  1. Abbreviations: hrHPV high-risk human papilloma virus, TCT thin-prep cytology test, Ascus atypical squamous cell of undetermined significance, LSIL low-grade squamous intraepithelial lesion, HSIL high-grade squamous intraepithelial lesion, ASC-H atypical squamous cell- cannot exclude HSIL
  2. *: P values were calculated by ANOVA, Chi-square test or Fisher exact probability test
  3. a: “-” means no sense; b: HPV subtypes might overlap in each participant; c: Methods of contraception means the most common way of birth control