Fig. 3

Heatmap of relative microbiome abundance found in vaginal samples obtained from 297 women with IS-pro. Column correlation clustering was performed with the UPGMA method to cluster microbiome profiles according to similarity based on cosine correlation. Row hierarchy clustering was performed calculating the Euclidean distance based on hierarchical analysis to identify and order the most prominent taxa related to the microbiome profiles. Shown in the figure are the 19 most abundant taxa found in this correlation. The alpha diversity is shown in the bar graph using the Shannon diversity index in a sample order correlating with the above heatmap profiles