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Fig. 3 | BMC Microbiology

Fig. 3

From: Zinc limitation in Klebsiella pneumoniae profiled by quantitative proteomics influences transcriptional regulation and cation transporter-associated capsule production

Fig. 3

Secretome profiling of K. pneumoniae cultured in zinc-limited and -replete media. a Venn diagram depicting total proteins identified in limited (red, 56) and replete (blue, 8) conditions. b Principal component analysis. Variance amongst biological replicates of cells grown in limited (red, right) and replete (blue, left) conditions separated based on component 1 (38.7%) and component 2 (16.9%). c Pie chart depicting Gene Ontology Cellular Compartment categories and presence of signal peptide. d Volcano plot depicting proteins present in secretome. Proteins in blue (right) are significantly abundant under replete conditions. Proteins in red (left) are significantly abundant under limited conditions. Statistical analysis was performed using a Student’s t-test (p-value ≤0.05; FDR = 0.05; S0 = 1). Experiment performed in biological quadruplicate and technical duplicate

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