Low levels of HIV-1 drug resistance mutations in patients who achieved viral re-suppression without regimen switch: a retrospective study

Table 2 Characteristics* of the patients successfully genotyped (N = 57)

Category	Parameters	Characteristics	Total [N (% or IQR)]	^#P-Values
Demographics	Sex	Female	39 (68)	0.042
	Sex	Male	18 (32)	0.042
	Age at baseline	Median (IQR) years	34 (30–42)	0.921
	Marital Status	Single	12 (21)	0.663
		Married	29 (51)
		Divorced/Separated	4 (7)
		Widowed	12 (21)
	Education	None	6 (11)	0.770
		Primary	14 (25)
		Secondary	18 (32)
		Tertiary	19 (33)
	Occupation	Not Employed	15 (26)	0.338
	Occupation	Employed	42 (74)	0.338
Clinical Parameters	First-line Backbone NRTI	AZT	34 (60)	0.978
		TDF	16 (28)
		^bOthers	7 (12)
	First-line Second NRTI	3TC	39 (68)	0.666
	First-line Second NRTI	FTC	18 (32)	0.666
	First-line NNRTI	NVP	43 (75)	0.071
	First-line NNRTI	EFV	14 (25)	0.071
	Time on First-line ART (Months)	ART Initiation to F₁	21 (12–36)	0.217
		F₁ to F_C	5 (4–6)	0.086
		F_C to Viral Re-suppression	5 (3–10)	0.118
Laboratory Parameters	Baseline CD4+ cells/μL	< 200	38 (67)	0.780
		200–350	17 (30)
		> 350	2 (4)
		Median (IQR)	155 (105–235)
	Baseline Viral Load (VL), copies/mL	≤100,000	36 (63)	0.774
		> 100,000	18 (32)
		Unknown	3 (5)
		Median (IQR)	43,587 (13128–176,990)
	VL at initial failure (copies/mL)	Median (IQR)	9113 (3680–49,670)	0.768
	VL at confirmatory failure (copies/mL)	Median (IQR)	16,266 (2042–4,002,513)	0.454
	HIV-1 Subtype	G	25 (44)	0.261 Grouped as G, CRF02_AG and Others
		CRF02_AG	23 (40)
		A	3 (5)
		CRF06_cpx	3 (5)
		J	1 (2)
		C	1 (2)
		Recombinant of A1, G	1 (2)

^aDemographic characteristics of those successfully genotyped were not significantly different from those not genotyped; F₁ First VL ≥ 1000 cp/mL; F_C Second VL ≥ 1000 cp/mL. ^#P-value is for difference in patient characteristic and drug resistance. IQR Interquartile range. ^bOthers = Backbone NRTI was switched

ISSN: 1471-2180