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Table 4 Conserved TFBSs predicted by Mulan (https://mulan.dcode.org/) to be conserved (100%) between human, chimpanzee, rhesus monkey, cow and domesticated dog at the [−368_ + 10] region. The most important transcription factor Sp1 for IL1B transcription was not included in this list

From: First insights into the molecular basis association between promoter polymorphisms of the IL1B gene and Helicobacter pylori infection in the Sudanese population: computational approach

Transcription Factor

Binding sequence

Positiona

Conserved SNPs

Start

End

HNF4_01

TCTTCCACTTTGTCCCACA

− 344

− 326

rs140623868 [− 335]

-338A > Tb

DR1_Q3

TCCACTTTGTCCC

− 341

− 329

PPAR_DR1_Q2

TCCACTTTGTCCC

−341

−329

NFKAPPAB65_01

GGAAAATCCA

− 295

− 286

 

OCT1_01

TGCATATTTGCATGGTGAT

− 236

− 220

rs749558279 [− 224]

OCT1_Q5_01

ATATTTGCATG

− 235

−225

 

OCT_Q6

ATATTTGCATG

−235

−225

 

OCT1_B

TATTTGCATG

− 234

−225

 

AP1_Q2_01

CAAAATGTGTCA

− 212

− 201

 

ZTA_Q2

TGTGTCATAGTTT

−207

− 196

 

CEBPDELTA_Q6

GATTGTGAAATC

−93

−82

 

BARBIE_01

ACTTCTGCTTTTGAA

−49

−35

 
  1. aAll positions are given in base pairs relative to the translational IL1B start codon (transcript NM_000576.3)
  2. bObserved in this study