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Table 4 Conserved TFBSs predicted by Mulan (https://mulan.dcode.org/) to be conserved (100%) between human, chimpanzee, rhesus monkey, cow and domesticated dog at the [−368_ + 10] region. The most important transcription factor Sp1 for IL1B transcription was not included in this list

From: First insights into the molecular basis association between promoter polymorphisms of the IL1B gene and Helicobacter pylori infection in the Sudanese population: computational approach

Transcription Factor Binding sequence Positiona Conserved SNPs
Start End
HNF4_01 TCTTCCACTTTGTCCCACA − 344 − 326 rs140623868 [− 335]
-338A > Tb
DR1_Q3 TCCACTTTGTCCC − 341 − 329
PPAR_DR1_Q2 TCCACTTTGTCCC −341 −329
NFKAPPAB65_01 GGAAAATCCA − 295 − 286  
OCT1_01 TGCATATTTGCATGGTGAT − 236 − 220 rs749558279 [− 224]
OCT1_Q5_01 ATATTTGCATG − 235 −225  
OCT_Q6 ATATTTGCATG −235 −225  
OCT1_B TATTTGCATG − 234 −225  
AP1_Q2_01 CAAAATGTGTCA − 212 − 201  
ZTA_Q2 TGTGTCATAGTTT −207 − 196  
CEBPDELTA_Q6 GATTGTGAAATC −93 −82  
BARBIE_01 ACTTCTGCTTTTGAA −49 −35  
  1. aAll positions are given in base pairs relative to the translational IL1B start codon (transcript NM_000576.3)
  2. bObserved in this study