The identification of co-expressed gene modules in Streptococcus pneumonia from colonization to infection to predict novel potential virulence genes

Table 3 The key infection-related genes were not categorized as DEGs but detected by the SPD algorithm

SPD Modules	Gene name	Role in the infection process	Reference (s)
14 (Nasopharynx, lung)	SP_0054	Early response gene in human lung epithelial cells	[8]
	SP_0274	Essential gene in lung infection	[17]
	SP_1460	Involved in iron starvation condition	[16]
	SP_1780	Essential gene in pulmonary infection	[17]
17 (Nasopharynx, lung)	SP_2176	Enriched in Two-component system which controls the virulence and bacterial resistance to oxidative stress	[11, 12]
101(lung, blood)	SP_1923	Vaccine candidate gene	[19]
22 (lung, blood)	SP_0215	Enriched in nitrogen compound metabolism and primary metabolic process which is dysregulated in copper resistance in Streptococcus pneumonia	[18]
	SP_1540		[18]
	SP_1105	Enriched in the metabolic process of nitrogen compounds	[18]
130 (blood, brain)	SP_0739	Up-regulated in response to exposure to penicillin	[23]
130 (blood, brain)	SP_1052	Contributes to virulence in mice	[24]

ISSN: 1471-2180