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Table 7 Levels of serum biochemical indices of male and female (mice) treated orally with P. acidilactici J9 for 14 days

From: Two-weeks repeated-dose oral toxicity study of Pediococcus acidilactici J9 in a mice model

Sex Parameters Dose (mg)
Control 500 1000 2000
Male Glu 256.40 ± 11.91 243.00 ± 42.57 234.20 ± 25.82 230.80 ± 31.32
BUN 18.68 ± 3.87 21.54 ± 5.78 20.50 ± 6.22 18.24 ± 2.60
Crea 0.28 ± 0.04 0.29 ± 0.02 0.27 ± 0.02 0.27 ± 0.03
T-Chol 79.00 ± 4.36 85.20 ± 4.92 82.40 ± 6.80 81.80 ± 4.66
TP 4.74 ± 0.05 4.82 ± 0.24 4.76 ± 0.11 4.68 ± 0.16
ALB 1.70 ± 0.07 1.72 ± 0.08 1.68 ± 0.04 1.68 ± 0.13
T-BIL 0.06 ± 0.05 0.04 ± 0.05 0.08 ± 0.04 0.08 ± 0.04
ALP 133.00 ± 19.51 137.80 ± 9.65 126.20 ± 19.82 137.40 ± 15.96
AST (GOT) 56.20 ± 15.07 65.20 ± 13.18 48.00 ± 7.35 57.40 ± 13.28
ALT (GPT) 28.80 ± 4.15 28.00 ± 4.18 22.20 ± 1.30 25.20 ± 4.49
TG 66.40 ± 26.88 64.40 ± 31.45 49.80 ± 23.85 39.40 ± 17.94
A/G 0.56 ± 0.05 0.56 ± 0.05 0.52 ± 0.04 0.56 ± 0.05
B/C 66.61 ± 12.59 74.13 ± 18.80 76.83 ± 22.46 69.05 ± 11.10
Female Glu 214.40 ± 37.40 229.60 ± 47.45 228.40 ± 40.32 231.00 ± 66.87
BUN 25.16 ± 5.42 24.70 ± 5.07 23.06 ± 3.26 22.58 ± 4.50
Crea 0.27 ± 0.05 0.25 ± 0.05 0.28 ± 0.03 0.26 ± 0.03
T-Chol 76.80 ± 8.11 70.20 ± 5.97 78.80 ± 13.44 80.00 ± 9.85
TP 4.82 ± 0.08 4.72 ± 0.16 4.78 ± 0.20 4.70 ± 0.23
ALB 1.74 ± 0.05 1.74 ± 0.05 1.74 ± 0.05 1.72 ± 0.04
T-BIL 0.00 ± 0.00 0.02 ± 0.04 0.02 ± 0.04 0.02 ± 0.04
ALP 168.20 ± 8.93 173.40 ± 10.31 154.20 ± 13.88 153.60 ± 26.37
AST (GOT) 68.20 ± 17.02 67.60 ± 14.57 66.80 ± 8.20 78.40 ± 18.01
ALT (GPT) 21.00 ± 12.88 22.80 ± 3.11 24.60 ± 3.51 23.00 ± 3.39
TG 0.56 ± 0.05 43.00 ± 9.70 27.00 ± 3.00 34.20 ± 15.45
A/G 0.56 ± 0.05 0.58 ± 0.04 0.56 ± 0.05 0.58 ± 0.04
B/C 94.97 ± 12.02 103.82 ± 32.56 82.32 ± 13.29 87.08 ± 24.74
  1. Values are expressed as mean ± SE (n = 5)
  2. NS not significantly different among groups