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Table 7 Levels of serum biochemical indices of male and female (mice) treated orally with P. acidilactici J9 for 14 days

From: Two-weeks repeated-dose oral toxicity study of Pediococcus acidilactici J9 in a mice model

Sex

Parameters

Dose (mg)

Control

500

1000

2000

Male

Glu

256.40 ± 11.91

243.00 ± 42.57

234.20 ± 25.82

230.80 ± 31.32

BUN

18.68 ± 3.87

21.54 ± 5.78

20.50 ± 6.22

18.24 ± 2.60

Crea

0.28 ± 0.04

0.29 ± 0.02

0.27 ± 0.02

0.27 ± 0.03

T-Chol

79.00 ± 4.36

85.20 ± 4.92

82.40 ± 6.80

81.80 ± 4.66

TP

4.74 ± 0.05

4.82 ± 0.24

4.76 ± 0.11

4.68 ± 0.16

ALB

1.70 ± 0.07

1.72 ± 0.08

1.68 ± 0.04

1.68 ± 0.13

T-BIL

0.06 ± 0.05

0.04 ± 0.05

0.08 ± 0.04

0.08 ± 0.04

ALP

133.00 ± 19.51

137.80 ± 9.65

126.20 ± 19.82

137.40 ± 15.96

AST (GOT)

56.20 ± 15.07

65.20 ± 13.18

48.00 ± 7.35

57.40 ± 13.28

ALT (GPT)

28.80 ± 4.15

28.00 ± 4.18

22.20 ± 1.30

25.20 ± 4.49

TG

66.40 ± 26.88

64.40 ± 31.45

49.80 ± 23.85

39.40 ± 17.94

A/G

0.56 ± 0.05

0.56 ± 0.05

0.52 ± 0.04

0.56 ± 0.05

B/C

66.61 ± 12.59

74.13 ± 18.80

76.83 ± 22.46

69.05 ± 11.10

Female

Glu

214.40 ± 37.40

229.60 ± 47.45

228.40 ± 40.32

231.00 ± 66.87

BUN

25.16 ± 5.42

24.70 ± 5.07

23.06 ± 3.26

22.58 ± 4.50

Crea

0.27 ± 0.05

0.25 ± 0.05

0.28 ± 0.03

0.26 ± 0.03

T-Chol

76.80 ± 8.11

70.20 ± 5.97

78.80 ± 13.44

80.00 ± 9.85

TP

4.82 ± 0.08

4.72 ± 0.16

4.78 ± 0.20

4.70 ± 0.23

ALB

1.74 ± 0.05

1.74 ± 0.05

1.74 ± 0.05

1.72 ± 0.04

T-BIL

0.00 ± 0.00

0.02 ± 0.04

0.02 ± 0.04

0.02 ± 0.04

ALP

168.20 ± 8.93

173.40 ± 10.31

154.20 ± 13.88

153.60 ± 26.37

AST (GOT)

68.20 ± 17.02

67.60 ± 14.57

66.80 ± 8.20

78.40 ± 18.01

ALT (GPT)

21.00 ± 12.88

22.80 ± 3.11

24.60 ± 3.51

23.00 ± 3.39

TG

0.56 ± 0.05

43.00 ± 9.70

27.00 ± 3.00

34.20 ± 15.45

A/G

0.56 ± 0.05

0.58 ± 0.04

0.56 ± 0.05

0.58 ± 0.04

B/C

94.97 ± 12.02

103.82 ± 32.56

82.32 ± 13.29

87.08 ± 24.74

  1. Values are expressed as mean ± SE (n = 5)
  2. NS not significantly different among groups