From: Two-weeks repeated-dose oral toxicity study of Pediococcus acidilactici J9 in a mice model
Sex | Parameters | Dose (mg) | |||
---|---|---|---|---|---|
Control | 500 | 1000 | 2000 | ||
Male | Glu | 256.40 ± 11.91 | 243.00 ± 42.57 | 234.20 ± 25.82 | 230.80 ± 31.32 |
BUN | 18.68 ± 3.87 | 21.54 ± 5.78 | 20.50 ± 6.22 | 18.24 ± 2.60 | |
Crea | 0.28 ± 0.04 | 0.29 ± 0.02 | 0.27 ± 0.02 | 0.27 ± 0.03 | |
T-Chol | 79.00 ± 4.36 | 85.20 ± 4.92 | 82.40 ± 6.80 | 81.80 ± 4.66 | |
TP | 4.74 ± 0.05 | 4.82 ± 0.24 | 4.76 ± 0.11 | 4.68 ± 0.16 | |
ALB | 1.70 ± 0.07 | 1.72 ± 0.08 | 1.68 ± 0.04 | 1.68 ± 0.13 | |
T-BIL | 0.06 ± 0.05 | 0.04 ± 0.05 | 0.08 ± 0.04 | 0.08 ± 0.04 | |
ALP | 133.00 ± 19.51 | 137.80 ± 9.65 | 126.20 ± 19.82 | 137.40 ± 15.96 | |
AST (GOT) | 56.20 ± 15.07 | 65.20 ± 13.18 | 48.00 ± 7.35 | 57.40 ± 13.28 | |
ALT (GPT) | 28.80 ± 4.15 | 28.00 ± 4.18 | 22.20 ± 1.30 | 25.20 ± 4.49 | |
TG | 66.40 ± 26.88 | 64.40 ± 31.45 | 49.80 ± 23.85 | 39.40 ± 17.94 | |
A/G | 0.56 ± 0.05 | 0.56 ± 0.05 | 0.52 ± 0.04 | 0.56 ± 0.05 | |
B/C | 66.61 ± 12.59 | 74.13 ± 18.80 | 76.83 ± 22.46 | 69.05 ± 11.10 | |
Female | Glu | 214.40 ± 37.40 | 229.60 ± 47.45 | 228.40 ± 40.32 | 231.00 ± 66.87 |
BUN | 25.16 ± 5.42 | 24.70 ± 5.07 | 23.06 ± 3.26 | 22.58 ± 4.50 | |
Crea | 0.27 ± 0.05 | 0.25 ± 0.05 | 0.28 ± 0.03 | 0.26 ± 0.03 | |
T-Chol | 76.80 ± 8.11 | 70.20 ± 5.97 | 78.80 ± 13.44 | 80.00 ± 9.85 | |
TP | 4.82 ± 0.08 | 4.72 ± 0.16 | 4.78 ± 0.20 | 4.70 ± 0.23 | |
ALB | 1.74 ± 0.05 | 1.74 ± 0.05 | 1.74 ± 0.05 | 1.72 ± 0.04 | |
T-BIL | 0.00 ± 0.00 | 0.02 ± 0.04 | 0.02 ± 0.04 | 0.02 ± 0.04 | |
ALP | 168.20 ± 8.93 | 173.40 ± 10.31 | 154.20 ± 13.88 | 153.60 ± 26.37 | |
AST (GOT) | 68.20 ± 17.02 | 67.60 ± 14.57 | 66.80 ± 8.20 | 78.40 ± 18.01 | |
ALT (GPT) | 21.00 ± 12.88 | 22.80 ± 3.11 | 24.60 ± 3.51 | 23.00 ± 3.39 | |
TG | 0.56 ± 0.05 | 43.00 ± 9.70 | 27.00 ± 3.00 | 34.20 ± 15.45 | |
A/G | 0.56 ± 0.05 | 0.58 ± 0.04 | 0.56 ± 0.05 | 0.58 ± 0.04 | |
B/C | 94.97 ± 12.02 | 103.82 ± 32.56 | 82.32 ± 13.29 | 87.08 ± 24.74 |