TY - JOUR AU - Ren, Qun AU - Brenner, Rebecca AU - Boothby, Thomas C. AU - Zhang, Zhaojie PY - 2020 DA - 2020/11/10 TI - Membrane and lipid metabolism plays an important role in desiccation resistance in the yeast Saccharomyces cerevisiae JO - BMC Microbiology SP - 338 VL - 20 IS - 1 AB - Anhydrobiotes, such as the yeast Saccharomyces cerevisiae, are capable of surviving almost total loss of water. Desiccation tolerance requires an interplay of multiple events, including preserving the protein function and membrane integrity, preventing and mitigating oxidative stress, maintaining certain level of energy required for cellular activities in the desiccated state. Many of these crucial processes can be controlled and modulated at the level of organelle morphology and dynamics. However, little is understood about what organelle perturbations manifest in desiccation-sensitive cells as a consequence of drying or how this differs from organelle biology in desiccation-tolerant organisms undergoing anhydrobiosis. SN - 1471-2180 UR - https://doi.org/10.1186/s12866-020-02025-w DO - 10.1186/s12866-020-02025-w ID - Ren2020 ER -