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Table 2 Carbapenemase genes, MHT, mCIM, eCIM, and antibiotic susceptibility of 195 CRE isolates

From: Combination of modified carbapenem inactivation method (mCIM) and EDTA-CIM (eCIM) for phenotypic detection of carbapenemase-producing Enterobacteriaceae

Species

Carbapenemase-encoding genesa

No. of strains

MHT (n)

mCIM (n)

eCIM (n)

Carbapenem resistance (n)b

Neg

Pos

Neg

Pos

Neg

Pos

IPM

ETP

MEM

DOP

Citrobacter koseri

blaOXA-48

4

0

4

0

4

4

0

4

4

4

4

None

3

3

0

3

0

ND

ND

2

3

2

2

Enterobacter cloacae

blaIMP

2

1

1

0

2

0

2

2

2

2

2

blaOXA-48

1

0

1

0

1

1

0

0

1

1

0

None

9

9

0

9

0

ND

ND

4

9

2

3

Escherichia coli

blaKPC

5

0

5

0

5

5

0

5

5

5

5

blaNDM

11

6

5

0

11

0

11

11

11

11

11

blaOXA-48

13

1

12

0

13

12

1

10

13

10

11

blaNDM/blaOXA-48

3

1

2

0

3

2

1

3

3

3

3

None

18

18

0

18

0

ND

ND

10

16

6

5

Klebsiella aerogenes

blaVIM

1

1

0

0

1

0

1

1

1

1

1

blaNDM

1

0

1

0

1

0

1

1

1

1

1

None

6

5

1

6

0

ND

ND

5

6

3

2

Klebsiella pneumoniae

blaKPC

29

0

29

0

29

29

0

29

29

29

29

blaIMP

5

2

3

0

5

1

4

5

5

4

4

blaVIM

2

1

1

0

2

0

2

2

2

2

2

blaNDM

3

2

1

0

3

0

3

3

3

3

3

blaOXA-48

23

1

22

0

23c

23

0

22

23

22

21

blaKPC/blaOXA-48

2

0

2

0

2

2

0

2

2

2

2

None

54

53

1

54

0

ND

ND

28

54

25

23

Total

 

195

10

91

90

105

79

26

149

193

138

134

  1. aClass A carbapenemase, KPC; Class B carbapenemase, IMP, NDM, and VIM; Class D carbapenemase, OXA-48
  2. bAntibiotic susceptibility to carbapenems was determined by disc diffusion. IPM, imipenem; ETP, ertapenem; MEM, meropenem; DOP, doripenem
  3. cThe results of 2 mCIM tests were interpreted as “indeterminate” (pinpoint colonies were present within a 16- to 18-mm zone)
  4. Pos positive, Neg negative
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BMC Microbiology

ISSN: 1471-2180

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