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Table 1 Strain information and minimum inhibitory concentrations (MIC) of polymyxin B and resveratrol against bacterial isolates in this study

From: Resveratrol enhances the antimicrobial effect of polymyxin B on Klebsiella pneumoniae and Escherichia coli isolates with polymyxin B resistance

Isolate Source MIC Polymyxin susceptibility and mechanism of resistance
Res PB PB in the presence of 32 μg/ml Res PB in the presence of 64 μg/ml Res PB in the presence of 128 μg/ml Res
Klebsiella pneumoniae
 1 human 512 16 8 4 2 mcr-1
 2 human 512 > 512 > 512 128 2 Uncharacterized
 3 human 512 8 2 2 2 Uncharacterized
 4 human > 2048 4 2 1 1 Uncharacterized
 5 human > 2048 4 2 1 1 Uncharacterized
 6 human 512 > 512 > 512 256 8 Uncharacterized
 7 human 1024 8 2 2 2 Uncharacterized
 8 human > 2048 > 512 256 16 1 Uncharacterized
 9 human 2048 4 1 0.5 1 Uncharacterized
 10 human 2048 4 1 1 1 Uncharacterized
 11 human 512 4 2 2 1 Uncharacterized
 12 human > 2048 16 1 1 1 Uncharacterized
 13 human 2048 4 2 0.5 1 Uncharacterized
 14 human 2048 4 2 1 1 Uncharacterized
 15 human 2048 16 4 2 1 Uncharacterized
 16 human 2048 32 4 4 0.5 Uncharacterized
 17 human 2048 64 16 4 1 Uncharacterized
 18 human 512 4 1 0.5 0.5 Uncharacterized
 19 human > 2048 4 1 0.5 0.5 Uncharacterized
 20 human 512 256 128 32 1 Uncharacterized
 21 human 2048 16 2 2 0.5 Uncharacterized
 22 human > 2048 2 0.5 0.5 1 Susceptible
 23 human 512 2 1 0.5 1 Susceptible
 24 human 2048 2 2 0.5 0.5 Susceptible
 25 human > 2048 2 1 0.5 1 Susceptible
 26 human > 2048 2 1 1 1 Susceptible
Escherichia coli
 27 animal > 2048 4 2 2 1 mcr-1
 28 animal > 2048 4 2 2 1 mcr-1
 29 animal 2048 > 512 64 8 4 mcr-1
 30 animal > 2048 4 2 2 1 mcr-1
 31 animal > 2048 4 2 2 1 mcr-1
 32 animal > 2048 > 512 > 512 256 32 mcr-1
 33 animal > 2048 4 2 2 1 mcr-1
 34 animal > 2048 4 2 2 1 mcr-1
 35 animal 2048 4 4 2 1 mcr-1
 36 animal > 2048 4 2 2 1 mcr-1
 37 animal > 2048 4 2 2 1 mcr-1
 38 animal > 2048 4 2 2 1 mcr-1
 39 animal > 2048 > 512 > 512 128 8 mcr-1
 40 animal 2048 32 16 4 1 mcr-1
 41 animal > 2048 4 2 2 1 mcr-1
 42 animal > 2048 4 2 2 1 mcr-1
 43 animal > 2048 > 512 > 512 256 2 mcr-1
 44 animal > 2048 4 2 2 0.5 mcr-1
 45 animal 2048 64 4 4 0.5 mcr-1
 46 animal > 2048 4 2 2 0.5 mcr-1
 47 human 2048 4 1 0.5 0.5 mcr-1
 48 human > 2048 4 2 1 1 mcr-1
 49 animal 2048 32 8 2 1 Uncharacterized
 50 human 2048 2 2 1 1 Susceptible
  1. PB Stands for polymyxin B and Res stands for resveratrol