Fig. 7
From: The combined usage of Matrine and Osthole inhibited endoplasmic reticulum apoptosis induced by PCV2
Mechanism of anti-apoptosis induced by PCV2 or Cap using Matrine combined with Osthole through by ER pathway. The ‘arrow’ indicates a promoting effect, whereas red ‘T-shape’ indicates an inhibiting effect. Virus replication is inhibited by inhibiting the expression of apoptins in the PERK pathway of ER, further down-regulating the expression of downstream pro-apoptins cleaved caspase-3 and Bax, and up-regulating the expression of anti-apoptins Bcl-2