Proteins that interacts with bone matrix and osteoblasts cells | ||||||
---|---|---|---|---|---|---|
MSCRAMM(s) | Functional response | Mean peptide spectral count | References | |||
Planktonic condition | Biofilm condition | |||||
 |  | USA300 LAC | msaABCR mutant | USA300 LAC | msaABCR mutant |  |
Fibronectin binding protein A (FnbA) | Internalization | 2 | 0 | 81 | 128 | |
Fibronectin binding protein B (FnbB) | Internalization | – | – | 0 | 11* | |
Serine-aspartate repeat-containing proteins (SdrC) | Colonization | 0 | 8* | – | – | [43] |
Serine-aspartate repeat-containing proteins (SdrD) | Colonization | 36 | 12* | 0 | 2 | [43] |
Extracellular matrix binding protein (Embp) | Colonization | 7 | 2* | 0 | 3* | [44] |
Toxins and exoproteins involved in osteoblast cytotoxicity and induce osteoclastogenesis | ||||||
Toxins / exoproteins | Â | Â | Â | Â | Â | |
Alpha hemolysin (Hla) | Osteoblast/osteoclast cell death | 19 | 6* | – | – | |
Panton-Valentine leucocidin (PVL) | Persistence of infection | 37 | 24 | 203 | 308 | |
Uncharacterized leukocidin-like protein 1 (LukL1) | Osteoblast cytotoxicity | 215 | 83* | 232 | 332 | |
Staphylococcal protein A (SpA) | Induction of bone loss (apoptosis) and bone destruction (osteoclastogenesis), inhibits mineralization | – | – | 12 | 5* | |
Other virulence factors that plays role in osteomyelitis infection and immune evasion | ||||||
Virulence factors | Â | Â | Â | Â | Â | |
Serine protease (sspA) | modulates secreted osteolytic factors | 0 | 38* | – | – | |
Cysteine protease (SspB) | 12 | 66* | – | – |  | |
Cysteine protease (SspC) | 0 | 12* | 7 | 22* | Â | |
Aureolysin (Aur) | 0 | 60* | – | – |  | |
Staphopain A | immunomodulatory protein that blocks neutrophil recruitment | 37 | 31 | 0 | 5* | [54] |
Map protein | Immunomodulators interfering T cell mediated response | 85 | 0* | 116 | 0* | [55] |
Immunoglobulin-binding protein sbi | Immune evasion factor | 46 | 19* | 98 | 114 | [56] |
Clumping factor A (ClfA) | Unknown | 11 | 6 | 16 | 5* | [57] |
Clumping factor B (ClfB) | Unknown | 9 | 3* | 33 | 44 | [57] |