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Table 4 Cure rates according to two days of Kato-Katz (combined KK) and PCR for the four treatment arms

From: Comparison of real-time PCR and the Kato-Katz method for the diagnosis of soil-transmitted helminthiasis and assessment of cure in a randomized controlled trial

  Moxidectin Moxidectin/ tribendimidine Moxidectin/ albendazole Albendazole/ oxantel pamoate
Trichuris trichiura
 Combined KK (95% CI) 15.0 (8.0–24.7) 24.7 (15.8–35.5) 50 (38.6–61.4) 82.3 (72.1–90.0)
 OR combined KK (95% CI) 0.04 (0.02–0.09) 0.07 (0.03–0.15) 0.22 (0.1–0.44) 1.0
 PCR (95% CI) 13.0 (6.1–23.3) 12.8 (6.3–22.3) 41.0 (30.0–52.7) 79.2 (68.0–87.8)
 OR PCR (95% CI) 0.04 (0.02–0.1) 0.04 (0.02–0.09) 0.18 (0.09–0.38) 1.0
 Difference P = 0.73 P = 0.06 P = 0.26 P = 0.63
Hookworm
 KK (95% CI) 36.7 (19.9–56.1) 91.7 (77.5–98.2) 72.2 (54.8–85.8) 77.8 (60.8–89.9)
 OR KK (95% CI) 0.17 (0.06–0.49) 3.14 (0.76–13.0) 0.74 (0.25–2.17) 1.0
 PCR (95% CI) 8.3 (1.8–22.5) 82.6 (68.6–92.2) 37.1 (21.5–55.1) 57.1 (39.4–73.7)
 OR PCR (95% CI) 0.07 (0.02–0.27) 3.56 (1.29–9.83) 0.44 (0.17–1.16) 1.0
 Difference P = 0.009 P = 0.24 P = 0.004 P = 0.07
Ascaris lumbricoides
 KK (95% CI) 97.7 (87.7–99.9) 97.9 (88.7–99.9) 94.1 (83.8–98.8) 95.9 (86.0–99.5)
 OR KK (95% CI) 1.79 (0.16–20.4) 1.96 (0.17–22.3) 0.68 (0.11–4.26) 1.0
 PCR (95% CI) 97.4 (86.2–99.9) 94.2 (84.1–98.8) 94.0 (83.5–98.7) 89.6 (77.3–96.5)
 OR PCR (95%CI) 4.3 (0.48–38.5) 1.9 (0.43–8.42) 1.82 (0.41–8.08) 1.0
 Difference P = 0.93 P = 0.38 P = 0.98 P = 0.24
  1. OR: odds ratio of cure rates calculated for the regimens with moxidectin, moxidectin/tribendimidine and moxidectin/albendazole, respectively, compared to the albendazole/oxantel pamoate regimen, for both Kato-Katz and PCR methods;