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Table 1 Combination activity of CHL with VOR or NAT against Fusarium species

From: The combined utilization of Chlorhexidine and Voriconazole or Natamycin to combat Fusarium infections

Strains

Origin

MICs (μg/ml)

 

MICs (μg/ml)

 

CHL

VOR

CHL/VOR

FICI

NAT

CHL/NAT

FICI

F. Solani

 Jzfs1

Skin

> 16

4

1/0.5

SYN

8

2/8

N

 Jzfs2

Skin

> 16

2

1/0.5

SYN

8

2/8

N

 Jzfs3

Cornea

> 16

2

1/1

N

8

1/8

N

 Jzfs4

Cornea

> 16

8

2/0.5

SYN

4

2/4

N

 Jzfs5

Skin

> 16

2

2/0.5

SYN

8

2/8

N

 Jzfs6

Cornea

> 16

4

1/0.5

SYN

16

2/4

SYN

 Jzfs7

Skin

> 16

4

1/0.5

SYN

8

1/4

N

 Jzfs8

Auditory canal

> 16

2

1/0.5

SYN

8

1/4

N

 Jzfs9

Auditory canal

> 16

2

1/0.5

SYN

8

1/4

N

 Jzfs10

Nail

> 16

2

2/0.5

SYN

4

2/4

N

 Jzfs11

Nail

> 16

2

1/0.5

SYN

8

1/4

N

 Jzfs12

Cornea

> 16

4

1/0.5

SYN

8

1/4

N

F. oxysporum

 Jzfo1

Cornea

> 16

2

1/0.25

SYN

8

2/4

N

 Jzfo2

Nail

> 16

4

2/0.5

SYN

8

1/8

N

 Jzfo3

Skin

> 16

4

2/0.5

SYN

8

1/2

SYN

 Jzfo4

Skin

> 16

2

1/1

N

8

2/8

N

 Jzfo5

Cornea

> 16

2

1/0.25

SYN

8

2/4

N

 Jzfo6

Nail

> 16

2

1/0.5

SYN

4

1/4

N

 Jzfo7

Auditory canal

> 16

2

1/0.5

SYN

8

1/4

N

 Jzfo8

Nail

> 16

2

1/0.5

SYN

8

1/4

N

  1. SYN synergy (FICI ≤0.5), N indifference (no interaction 0.5 < FICI≤4), CHL Chlorhexidine, VOR Voriconazole, NAT Natamycin, MIC minimum inhibitory concentration, FICI Fractional inhibitory concentration index
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BMC Microbiology

ISSN: 1471-2180

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