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Table 1 Combination activity of CHL with VOR or NAT against Fusarium species

From: The combined utilization of Chlorhexidine and Voriconazole or Natamycin to combat Fusarium infections

Strains Origin MICs (μg/ml)   MICs (μg/ml)  
CHL VOR CHL/VOR FICI NAT CHL/NAT FICI
F. Solani
 Jzfs1 Skin > 16 4 1/0.5 SYN 8 2/8 N
 Jzfs2 Skin > 16 2 1/0.5 SYN 8 2/8 N
 Jzfs3 Cornea > 16 2 1/1 N 8 1/8 N
 Jzfs4 Cornea > 16 8 2/0.5 SYN 4 2/4 N
 Jzfs5 Skin > 16 2 2/0.5 SYN 8 2/8 N
 Jzfs6 Cornea > 16 4 1/0.5 SYN 16 2/4 SYN
 Jzfs7 Skin > 16 4 1/0.5 SYN 8 1/4 N
 Jzfs8 Auditory canal > 16 2 1/0.5 SYN 8 1/4 N
 Jzfs9 Auditory canal > 16 2 1/0.5 SYN 8 1/4 N
 Jzfs10 Nail > 16 2 2/0.5 SYN 4 2/4 N
 Jzfs11 Nail > 16 2 1/0.5 SYN 8 1/4 N
 Jzfs12 Cornea > 16 4 1/0.5 SYN 8 1/4 N
F. oxysporum
 Jzfo1 Cornea > 16 2 1/0.25 SYN 8 2/4 N
 Jzfo2 Nail > 16 4 2/0.5 SYN 8 1/8 N
 Jzfo3 Skin > 16 4 2/0.5 SYN 8 1/2 SYN
 Jzfo4 Skin > 16 2 1/1 N 8 2/8 N
 Jzfo5 Cornea > 16 2 1/0.25 SYN 8 2/4 N
 Jzfo6 Nail > 16 2 1/0.5 SYN 4 1/4 N
 Jzfo7 Auditory canal > 16 2 1/0.5 SYN 8 1/4 N
 Jzfo8 Nail > 16 2 1/0.5 SYN 8 1/4 N
  1. SYN synergy (FICI ≤0.5), N indifference (no interaction 0.5 < FICI≤4), CHL Chlorhexidine, VOR Voriconazole, NAT Natamycin, MIC minimum inhibitory concentration, FICI Fractional inhibitory concentration index