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Fig. 1 | BMC Microbiology

Fig. 1

From: Wogonin inhibits in vitro herpes simplex virus type 1 and 2 infection by modulating cellular NF-κB and MAPK pathways

Fig. 1

Wogonin inhibited HSV-induced CPEs and viral infectious particle formation in vitro. a Wogonin inhibited HSV-2-induced CPE development. HEC-1-A cells were mock-infected or infected with HSV-2 (G) (MOI = 1) in the presence or absence of wogonin (100 μM). Images were captured under an optical inverted microscope 24 h p.i. b and c Wogonin inhibited the formation of intracellular HSV-1/2 infectious viral particles. HEC-1-A cells were pretreated with serial concentrations of wogonin prior to infection with HSV- 1 (HF) or HSV-2 (G) (MOI = 1) for 24 h. The infectious viral particles were released by freeze and thaw cycles, and viral infectivity was titrated via measurement of the PFUs as described. The titers of HSV-1/2 infectious virions are shown as the means ± the SDs from three separate experiments

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