TY - JOUR AU - Chu, Ying AU - Lv, Xiaowen AU - Zhang, Longfeng AU - Fu, Xingli AU - Song, Siwei AU - Su, Airong AU - Chen, Deyan AU - Xu, Lianhong AU - Wang, Yongfang AU - Wu, Zhiwei AU - Yun, Zhihua PY - 2020 DA - 2020/07/28 TI - Wogonin inhibits in vitro herpes simplex virus type 1 and 2 infection by modulating cellular NF-κB and MAPK pathways JO - BMC Microbiology SP - 227 VL - 20 IS - 1 AB - Wogonin, a natural flavonoid-like chemical compound, exhibits anti-inflammatory, antitumor, antiviral, neuroprotective, and anxiolytic effects by modulating a variety of cellular signaling pathways including PI3K-Akt, p53, nuclear factor κB (NF-κB), mitogen-activated protein kinase (MAPK) pathways. In this study, its antiviral effect against herpes simplex virus (HSV) type 1 and 2 (HSV-1 and HSV-2) replication was investigated. SN - 1471-2180 UR - https://doi.org/10.1186/s12866-020-01916-2 DO - 10.1186/s12866-020-01916-2 ID - Chu2020 ER -