First description of antimicrobial resistance in carbapenem-susceptible Klebsiella pneumoniae after imipenem treatment, driven by outer membrane remodeling

Table 1 Phenotypic detection, distribution of resistance genes, MICs and virulence factors of antimicrobial agents among the K. pneumoniae isolates

Isolates codes	MHT¹⁾	EDTA	Resistance genes profiles	MIC (μg/ml)														Relative expression of		Virulence factors
Isolates codes	MHT¹⁾	EDTA	Resistance genes profiles	CRO²⁾	CAZ	CTX	IPM	MEM	ETP	LEV	CIP	TOB	GEN	AMK	FOS	COL	TGC	*ompK35*	*ompK36*
FK-2624	–	–	bla_SHV-187,oqxA. fosA5, bla_TEM-116	0.5	1	0.5	0.125	0.03	0.03	0.5	0.5	0.5	1	1	256	0.25	2	0.93	12.67	K57, ybtA, ICEKp6, mrkD, entB, iroN, rmpA2–6, wzi16, rmpA-2(KpVP-1)
FK-2723	–	–	bla_SHV-12, bla_DHA-1qnrB4, oqxA, aac(6′)–IIc, fosA5, EreA2, CatA2, SulI, TetD	8	> 64	16	1	0.25	0.5	8	4	128	32	4	> 1024	1	1	1.61	1.39	K57, ybtA, ICEKp6, mrkD, entB, iroN, rmpA2–6, wzi16
FK-2820	–	–	bla_SHV-12, bla_DHA-1qnrB4, oqxA, aac(6′)–IIc, fosA5, EreA2, CatA2, SulI, TetD	8	> 64	64	8	1	> 16	8	4	128	64	16	> 1024	1	1	1.44	0.093	K57, ybtA, ICEKp6, mrkD, entB, iroN, rmpA2–6, wzi16

Note:¹⁾MHT Modified Hodge test, EDTA EDTA synergy test
²⁾CRO Ceftriaxone, CAZ Ceftazidime, CTX Cefotaxime, IPM Imipenem, MEM Meropenem, ETP Ertapenem, LEV Levofloxacin, CIP Ciprofloxacin, TOB Tobramycin, GEN Gentamicin, AMK Amikacin, FOS Fosfomycin, COL Colistin, TGC Tigecycline

ISSN: 1471-2180