Fig. 1
From: Opportunistic detection of Fusobacterium nucleatum as a marker for the early gut microbial dysbiosis
Schematic diagram of metagenome analysis. Longitudinal metagenome data from IBDMD were filtered by indicated criteria, and basic characteristics of microbiome were profiled. Based on longitudinal experience of F. nucleatum and temporal distribution toward F. nucleatum-detected samples, microbial characteristics was compared. Using LEfSe algorithms, microbial biomarkers of non-IBD or common IBD condition were screened, and correlation of the marker species with F. nucleatum was assessed. After identifying classifier microbes, which significantly differentiate F. nucleatum-observed point, probability of experiencing F. nucleatum was estimated in F. nucleatum-innocent subjects using multiple logistic regression models. At last, microbes were classified into 9 clusters according to five longitudinal features associated with inflammatory conditions and F. nucleatum experience. Particular clusters contained a significant number of disease-associated marker species or well-known probiotics