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Table 5 The linkage of QRDRs mutations with antimicrobial susceptibility profile

From: Prevalence, serotypes, and antimicrobial resistance of Salmonella isolates from patients with diarrhea in Shenzhen, China

Isolate No.

Serotype

MAR

MIC (μg/ml)

Mutations-changes in codons

CIP

LEV

gyrA

gyrB

parC

parE

1

Typhimurium

0.33

<=0.25

<=0.12

–

–

–

–

2

Typhimurium

0.46

0.5

0.5

–

–

–

–

3

Typhimurium

0.63

1

2

–

CTT → CTC, TCC → TCTc

GTT → GTC, CAC → CAT, CAT→CAC, GCG → GCA, TCC → TCTd

ACT→ACGe, CAC → CATf

4

Bovismorbificans

0.38

1

0.5

GAC → GGCa

CTT → CTC, TCC → TCT

–

ACT, CAC → CAT

5

Typhimurium

0.50

1

0.5

GAC → GGC

CTT → CTC, TCC → TCT

–

ACT, CAC → CAT

6

Enteritidis

0.33

0.5

2

–

CTT → CTC, TCC → TCT

–

ACT, CAC → CAT

7

London

0.33

1

1

–

CTT → CTC, TCC → TCT

GTT → GTC, CAC → CAT, CAT→CAC, GCG → GCA, TCC → TCT

ACT, CAC → CAT

8

Typhimurium

0.33

2

1

GAC → AACb

–

–

–

9

Agona

0.63

1

1

–

CTT → CTC, TCC → TCT

GTT → GTC, CAC → CAT, CAT→CAC, GCG → GCA, TCC → TCT

ACT→ACG, CAC → CAT

10

London

0.42

1

1

GAC → AAC

CTT → CTC, TCC → TCT

GTT → GTC, CAC → CAT, CAT→CAC, GCG → GCA, TCC → TCT

–

11

Litchfield

0.25

1

1

GAC → AAC

CTT → CTC, TCC → TCT

–

–

12

4, 5, 12, i: -

0.21

1

1

–

–

–

–

13

Enteritidis

0.08

1

1

GAC → AAC

CTT → CTC, TCC → TCT

–

ACT, CAC → CAT

14

London

0.13

2

0.5

GAC → AAC

CTT → CTC, TCC → TCT

GTT → GTC, CAC → CAT, CAT→CAC, GCG → GCA, TCC → TCT

ACT→ACG, CAC → CAT

15

4, 5, 12, i: -

0.50

2

2

GAC → AAC

–

–

–

16

untypable

0.42

2

4

GAC → AAC

–

–

–

17

4, 5, 12, i: -

0.42

> = 4

4

GAC → AAC

–

–

–

18

Typhimurium

0.42

2

2

GAC → AAC

–

–

–

19

Typhimurium

0.63

> = 4

> = 8

GAC → AAC

–

–

–

20

Typhimurium

0.46

2

4

GAC → AAC

–

–

–

21

Typhimurium

0.58

> = 4

4

GAC → AAC

–

–

–

  1. Base pair changes in bold type.
  2. MIC minimum inhibitory concentration, CIP ciprofloxacin, LEV levofloxacin.
  3. - No mutation
  4. aAmino acid alteration is Asp-87 → Gly.
  5. bAmino acid alteration is Asp-87 → Asn.
  6. cAmino acid alterations are Leu-462 → Leu, Ser-464 → Ser.
  7. dAmino acid alterations are Val-67 → Val, His-75 → His, His-77 → His, Ala-117 → Ala, Ser-123 → Ser.
  8. eAmino acid alteration is Thr-500 → Thr.
  9. fAmino acid alteration is His-509 → His.
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BMC Microbiology

ISSN: 1471-2180

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