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Table 1 Surface exposed proteins of R. akari

From: Proteomic analysis of Rickettsia akari proposes a 44 kDa-OMP as a potential biomarker for Rickettsialpox diagnosis

Uniprot Accession Number

Description

mW (KDa)

pI

Identified by:

Subcellular localization

Predicted Motifs

Immunogenic

PSORTb

SOSUIgramN

β-barrel scorea

Signal P Type (Likelihood)

A8GQ33

Putative adhesin A1C_06425

24.1

9.7

B/T/S

outer membrane

outer membrane

2.819a

Sec/SPI (0.9982)

A8GMA6

50S ribosomal protein L7/L12

13.0

5.0

B/T/S

multiple

cytoplasmic

2.851a

no

A8GPL7

Outer membrane protein B

167.9

5.0

B/T/S

outer membrane

extracellular

2.861a

Sec/SPI (0.3494) Tat/SPI (0.5171)

yes

A8GPB6

60 kDa chaperonin

58.7

5.3

B/T/S

cytoplasmic

cytoplasmic

2.886a

no

yes

A8GM15

Putative surface antigen

48.1

9.6

B

inner membrane

extracellular

2.898a

Sec/SPI (0.9979)

A8GN82

Malate dehydrogenase

33.6

5.4

T /S

cytoplasmic

cytoplasmic

2.901a

no

A8GN16

Membrane protease subunits

33.9

5.5

T /S

unknown

inner membrane

2.902a

no

A8GPV8

Rod shape-determining protein MreB

37.4

5.3

T /S

cytoplasmic

cytoplasmic

2.912a

no

A8GMZ9

ATP-dependent protease subunit HslV

19.8

6.7

T

cytoplasmic

cytoplasmic

2.932a

no

A8GM33

Elongation factor Ts

33.7

5.2

T /S

cytoplasmic

cytoplasmic

2.932a

no

A8GM25

Preprotein translocase subunit SecG

6.5

9.5

B

unknown

unknown

2.936a

no

A8GMB0

Probable cytosol aminopeptidase

53.3

6.0

T /S

cytoplasmic

cytoplasmic

2.939a

no

A8GPZ4

ATP synthase subunit beta

51.0

4.6

T /S

multiple

cytoplasmic

2.940a

no

A8GP69

Phospho-N-acetylmuramoyl-pentapeptide-transferase

39.7

8.4

B

inner membrane

inner membrane

2.946a

no

A8GPZ6

ATP synthase subunit alpha

56.2

6.4

B/T/S

cytoplasmic

cytoplasmic

2.947a

no

A8GNC4

Uncharacterized protein

9.1

8.6

B/S

unknown

outer membrane

2.948a

Sec/SPII (0.9985)

A8GMH0

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

30.0

7.0

T /S

cytoplasmic

cytoplasmic

2.950a

no

A8GMS9

Heat shock protein

18.6

9.2

T /S

unknown

outer membrane

2.954a

no

A8GP63

Uncharacterized protein

44.6

8.5

B/T/S

unknown

extracellular

2.957a

Sec/SPI (0.9890)

yes

A8GMF9

Chaperone protein DnaK

67.7

4.8

B/T/S

cytoplasmic

cytoplasmic

2.960aa

no

yes

A8GNU1

Aminotran_5 domain-containing protein

40.7

6.7

T

cytoplasmic

cytoplasmic

2.961a

no

A8GLV8

ATP synthase subunit a

27.3

9.0

B

inner membrane

inner membrane

2.962a

no

A8GNF1

4-hydroxy-tetrahydrodipicolinate synthase

32.4

7.2

T

cytoplasmic

cytoplasmic

2.962a

no

A8GPZ9

Strees induced DNA-binding protein

16.1

4.9

B/T/S

cytoplasmic

cytoplasmic

2.963a

no

A8GLX8

50S ribosomal protein L9

19.4

7.7

B/S

cytoplasmic

cytoplasmic

2.964a

no

A8GML3

Uncharacterized protein

61.3

5.5

T /S

outer membrane

inner membrane

2.986

no

A8GP43

Protein export protein prsA

31.4

9.4

T /S

outer membrane

cytoplasmic

2.989

Sec/SPI (0.9958)

A8GP34

Uncharacterized protein

19.5

5.7

B/S

unknown

extracellular

2.990

Sec/SPI (0.9796)

A8GMM4

Tail-specific protease

50.1

7.3

T /S

inner membrane

outer membrane

2.990

Sec/SPI (0.8945)

A8GNE2

Uncharacterized protein

18.8

9.0

T

unknown

periplasmic

2.993

Sec/SPI (0.9866)

A8GPM2

Uncharacterized protein

17.0

6.2

B/S

unknown

extracellular

3.006

Sec/SPI (0.9979)

A8GP67

Actin polymerization protein RickA

59.6

10.1

T /S

outer membrane

extracellular

3.035

no

A8GPW0

Peptidoglycan-associated lipoprotein

17.5

8.9

T /S

outer membrane

unknown

3.106

Sec/SPII (0.9996)

yes

  1. SEPs detected using, B biotinylation, T Triton X-114, and/or S Shotgun proteomic approaches. avalues below the threshold 2.965 indicate the presence of beta-barrel structure