Table 2 Morphological analysis of B. pseudomallei strains in the presence of AMC and CAZ
Strain | AMC MIC (μg/ml) | Filamentation (4 h) | Time (h) cell lysis begins | |||||
|---|---|---|---|---|---|---|---|---|
½ MIC | MIC | MIC | 2x MIC | 4x MIC | ||||
# Cells ≥ 15 μm | Median CL (μm) | # Cells ≥ 15 μm | Median CL (μm) | |||||
Bp1651 | 64/32 (R) | 6/100 | 5 | 0/100 | 4 | 3.7 ± 0.0 | not tested | not tested |
MSHR1655 | 32/16 (R) | 62/100 | 19.5 | 61/100 | 19 | 6.1 ± 0.2 | 4.0 ± 0.3 | not tested |
724644 | 16/8 (I) | 93/100 | 59 | 24/100 | 6 | 4.8 ± 1.0 | 2.9 ± 0.2 | 2.9 ± 0.2 |
6788 | 8/4 (S) | 86/97 | 43 | 82/100 | 42.5 | remains filamentous | filaments and spheroplasts | only spheroplasts |
1026b | 4/2 (S) | 42/100 | 12 | 80/97 | 44 | remains filamentous | remains filamentous | 5.2 ± 0.4 |
Strain | CAZ MIC (μg/ml) | Filamentation (4 h) | Time (h) cell lysis begins | |||||
½ MIC | MIC | MIC | 2x MIC | 4x MIC | ||||
# Cells ≥ 15 μm | Median CL (μm) | # Cells ≥ 15 μm | Median CL (μm) | |||||
Bp1651 | > 128 (R) | 49/100* | 14* | 39/100* | 10.5* | filaments and spheroplasts* | not tested | not tested |
724644 | 8 (S) | 93/100 | 56.5 | 95/100 | 59.5 | remains filamentous | remains filamentous | remains filamentous |
MSHR1655 | 4 (S) | 48/100 | 13 | 61/100 | 22 | 8.2 ± 0.4 | 8.0 ± 0.0 | 8.0 ± 0.3 |
1026b | 2 (S) | 28/100 | 8 | 94/100 | 36 | remains filamentous | remains filamentous | remains filamentous |