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Table 2 Resistance mechanisms of 76 mupirocin, fusidic acid and/or retapamulin-resistant clinical MRSA isolates

From: Prevalence and molecular characterization of methicillin-resistant Staphylococcus aureus with mupirocin, fusidic acid and/or retapamulin resistance

 

Mupirocin

Fusidic acid

Retapamulin

Strain

Phenotype

mupA

mupB

IleS mutation

Phenotype

Mutation

fusB

fusC

fusD

Phenotype

Mutation

cfr

vagA/Av/ALC/B/C/E

lsaA-C

lsaE

salA

Smr

Mrm

Lmr

Fus A

Fus E

rplC

23S rRNA V

PT300

MuL

–

–

N213D

V588F

–

S

     

S

       

546

MuL

–

–

N213D

–

–

S

     

S

       

532

MuL

–

–

N213D

–

–

S

     

S

       

472

MuL

–

–

N213D

–

–

S

     

S

       

526

MuL

–

–

N213D

–

–

S

     

S

       

606

MuL

–

–

N213D

–

–

S

     

S

       

673

MuL

–

–

N213D

–

–

S

     

S

       

777

MuL

–

–

N213D

–

–

S

     

S

       

635

MuL

–

–

N213D

–

–

S

     

S

       

575

MuL

–

–

N213D

–

–

S

     

S

       

WU9

MuL

–

–

N213D

V588F

–

S

     

S

       

308

MuL

–

–

N213D

–

–

S

     

S

       

110

S

     

FAH

L461K

–

–

+

–

S

       

829

S

     

FAH

H457Q

–

–

+

–

S

       

PT301

S

     

FAH

L461K

–

–

+

–

S

       

PT308

S

     

FAH

L461K

–

–

+

–

S

       

LY26

S

     

FAH

E8K, V90I, L461K

–

–

–

–

S

       

LY32

S

     

FAH

H457Y

–

–

–

–

S

       

696

S

     

FAL

–

–

+

–

–

S

       

755

S

     

FAL

–

–

+

–

–

S

       

783

S

     

FAL

–

–

+

–

–

S

       

361

S

     

FAL

–

–

+

–

–

S

       

611SG

S

     

FAL

–

–

+

–

–

S

       

765

S

     

FAL

–

–

+

+

–

S

       

LS964

S

     

S

     

R

–

–

–

–

–

+

–

58

S

     

S

     

R

–

–

–

–

–

–

–

486

MuH

+

–

   

S

     

R

–

–

–

–

–

–

–

PT343

MuH

+

–

   

S

     

S

       

355

MuH

+

–

   

S

     

S

       

370

MuH

+

–

   

S

     

S

       

519

MuH

+

–

   

S

     

S

       

409

MuH

+

–

   

S

     

S

       

671

MuH

+

–

   

S

     

S

       

443

MuH

+

–

   

S

     

S

       

530

MuH

+

–

   

S

     

S

       

120

MuH

+

–

   

S

     

S

       

322

MuH

+

–

   

S

     

S

       

328

MuH

+

–

   

S

     

S

       

448

MuH

+

–

   

S

     

S

       

474

MuH

+

–

   

S

     

S

       

565

MuH

+

–

   

S

     

S

       

600

MuH

+

–

   

S

     

S

       

623

MuH

+

–

   

S

     

S

       

642

MuH

+

–

   

S

     

S

       

694

MuH

+

–

   

S

     

S

       

697

MuH

+

–

   

S

     

S

       

70

MuH

+

–

   

S

     

S

       

701

MuH

+

–

   

S

     

S

       

717

MuH

+

–

   

S

     

S

       

PT317

MuH

+

    

S

     

S

       

318

MuH

+

–

   

S

     

S

       

106

MuH

+

–

   

S

     

S

       

331

MuH

+

–

   

S

     

S

       

364

MuH

+

–

   

S

     

S

       

553

MuH

+

–

   

S

     

S

       

504

MuH

+

–

   

S

     

S

       

394

MuH

+

–

   

S

     

S

       

805

MuH

+

–

   

S

     

S

       

453

MuH

+

–

   

S

     

S

       

727

MuH

+

–

   

S

     

S

       

764

MuH

+

–

   

S

     

S

       

433

MuH

+

–

   

S

     

S

       

541

MuH

+

–

   

S

     

S

       

631

MuH

+

–

   

S

     

S

       

320

MuH

+

–

   

S

     

S

       

348

MuH

+

–

   

S

     

S

       

349

MuH

+

–

   

S

     

S

       

399

MuH

+

–

   

S

     

S

       

422

MuH

+

–

   

S

     

S

       

419

MuH

+

–

   

S

     

S

       

390

MuH

+

–

   

S

     

S

       

125

MuH

+

–

   

S

     

S

       

323

MuH

+

–

   

S

     

S

       

386

MuH

+

–

   

S

     

S

       

513

MuH

+

–

   

S

     

S

       

314

MuH

+

–

   

S

     

S

       
  1. MRSA, methicillin-resistant S. aureus; +, positive; —, negative or no mutation; IleS, isoleucyl-tRNA synthetase; MuH, high-level mupirocin resistance; MuL, low-level mupirocin resistance; FAH, high-level fusidic acid resistance; FAL, low-level fusidic acid resistance; vagA/Av/ALC/B/C/E, including vagA, vagAv, vagALC, vagB, vagC and vagE; lsaA-C, including lsaA, lsaB and lsaC R, resistance; S, susceptibility
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