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Fig. 4 | BMC Microbiology

Fig. 4

From: Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients

Fig. 4

Urinary metabolomics in IBS-D and HCs and correlations between faecal microbial abundances and discriminative metabolites. OPLS-DA scores plots for IBS-D (green) and HC (blue) samples in (a) ESI and (b) ESI+ modes of UHPLC-MS/MS. c Bubble plot of metabolic pathways associated with urinary metabolites differentiating IBS-D and HC group. Horizontal axis and bubble sizes indicate impact of pathways in topology analysis. Vertical axis and bubble color indicate - lg (P value) of pathways in enrichment analysis. d-e Heatmap of correlations between abundances of genera and metabolites associated with changed clinical scales in IBS-D (d) and HCs (e). Positive and negative correlations are shown in red and green blocks, respectively. Spearman’s correlation coefficients. * P < 0.05, ** P < 0.01

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