Effect of subinhibitory exposure to quaternary ammonium compounds on the ciprofloxacin susceptibility of Escherichia coli strains in animal husbandry

Maertens, H.; Demeyere, K.; De Reu, K.; Dewulf, J.; Vanhauteghem, D.; Van Coillie, E.; Meyer, E.

doi:10.1186/s12866-020-01818-3

Table 1 Viability (%) of each Escherichia coli isolate after different antibiotic treatments with and without exposure to benzalkonium chloride, expressed as mean +/− standard deviation

From: Effect of subinhibitory exposure to quaternary ammonium compounds on the ciprofloxacin susceptibility of Escherichia coli strains in animal husbandry

*E. coli* isolate - origin	MIC (mg/L CIP)	CIP treatment (mg/L)	Subpopulation	No BKC exposure			BKC exposure
KL6; Poultry	0.120; Resistant (non-WT)	0.000	Live	98.44	±	0.51	61.40	±	2.10
			Intermediate	0.35	±	0.17	20.71	±	0.79
			Dead	0.17	±	0.04	16.89	±	1.64
		0.064	Live	97.15	±	0.82	87.57	±	0.93
			Intermediate	1.02	±	0.55	9.77	±	1.02
			Dead	0.38	±	0.19	1.54	±	0.77
		0.640	Live	76.03	±	3.52	58.75	±	3.20
			Intermediate	18.73	±	4.12	35.67	±	2.58
			Dead	2.97	±	0.34	2.94	±	0.24
		6.400	Live	25.80	±	3.44	49.32	±	3.57
			Intermediate	68.14	±	2.37	44.96	±	4.84
			Dead	5.12	±	1.27	4.38	±	0.77
KQ26; Poultry	0.030; Susceptible* (WT)	0.000	Live	97.03	±	0.30	79.47	±	2.08
			Intermediate	0.95	±	0.18	4.17	±	0.58
			Dead	1.62	±	0.28	15.70	±	1.38
		0.064	Live	51.55	±	0.88	78.27	±	2.95
			Intermediate	42.48	±	1.32	17.34	±	2.13
			Dead	4.95	±	0.41	2.17	±	0.16
		0.640	Live	64.12	±	2.43	63.73	±	5.40
			Intermediate	30.96	±	1.64	31.46	±	5.65
			Dead	3.57	±	0.64	3.48	±	0.12
		6.400	Live	83.16	±	1.60	70.69	±	1.51
			Intermediate	12.91	±	1.30	26.86	±	1.50
			Dead	2.69	±	0.24	1.52	±	0.19
VA57; Pork	0.030; Susceptible* (WT)	0.000	Live	93.97	±	0.30	50.50	±	4.41
			Intermediate	1.37	±	0.02	9.88	±	0.66
			Dead	3.93	±	0.31	38.66	±	4.93
		0.064	Live	51.75	±	2.60	53.87	±	9.77
			Intermediate	34.45	±	3.60	35.97	±	7.70
			Dead	12.68	±	3.32	8.71	±	2.47
		0.640	Live	69.72	±	2.09	51.10	±	3.74
			Intermediate	14.59	±	0.63	40.18	±	2.64
			Dead	13.93	±	1.33	7.71	±	1.42
		6.400	Live	67.12	±	7.49	49.07	±	7.07
			Intermediate	26.31	±	5.79	44.51	±	7.12
			Dead	5.59	±	1.75	5.27	±	0.05
ATCC 10536	≤ 0.015; Susceptible* (WT)	0.000	Live	88.62	±	2.29	54.84	±	2.09
			Intermediate	2.74	±	0.22	6.76	±	1.39
			Dead	7.89	±	2.09	37.07	±	2.04
		0.064	Live	67.56	±	3.68	41.25	±	1.33
			Intermediate	22.19	±	3.79	54.12	±	2.47
			Dead	7.67	±	0.50	4.07	±	0.27
		0.640	Live	55.73	±	6.17	39.37	±	2.91
			Intermediate	38.62	±	7.95	56.31	±	2.47
			Dead	4.42	±	1.44	3.66	±	0.65
		6.400	Live	52.92	±	6.96	27.46	±	4.16
			Intermediate	44.05	±	5.56	67.88	±	4.45
			Dead	2.34	±	1.15	4.06	±	2.69

MIC Minimal Inhibitory Concentration, CIP ciprofloxacin, WT wild type; ^*susceptible/resistant to CIP, defined by the epidemiologic cutoff value (ECOFF, 0.064 mg/L CIP) separating the bacterial population into those without (wild type; <= 0.064 mg/L CIP ), and those with acquired resistance (non-wild type; > 0.064 mg/L CIP)

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