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Table 1 Predicted surface proteins after bacterial surface protein shaving of S. haemolyticus

From: Identification of surface proteins in a clinical Staphylococcus haemolyticus isolate by bacterial surface shaving

Accession

# PSM

# Unique Peptides

Fold change HaCaT vs Control

p-value HaCaT vs Control

LPxTG Cell-wall anchored

Prediction of subcellular localization

Preferred name, EggNOG

Annotation summary

ACAKHAOO_00208

8

7

1.75

0.046

–

Extracellular (SPI)

ymaC

DUF867 type protein

ACAKHAOO_02015

7

2

1.60

0.014

–

Extracellular (SPI)

sceD

Putative transglycosylase SceD

ACAKHAOO_00540

433

60

1.56

0.123

LPDTG

Cell Wall (SPI)

pelX

Serine-aspartate repeat-containing protein I / YSIRK-type signal peptide-containing protein

ACAKHAOO_01033

54

25

1.46

0.039

–

Extracellular (SPI)

atl

Bifunctional autolysin

ACAKHAOO_00522

6

3

1.35

0.054

LPNAG

Cell Wall (SPI)

sasH

Mannosylglucosyl-3-phosphoglycerate phosphatase

ACAKHAOO_00546

188

38

1.34

0.200

LPDTG

Cell Wall (SPI)

–

Serine-aspartate repeat-containing protein I / C protein alpha-antigen

ACAKHAOO_00080

6

5

1.24

0.143

LPKSG

Cell Wall (SPI)

–

Serine-aspartate repeat-containing protein D / YSIRK-type signal peptide-containing protein

ACAKHAOO_02469

10

3

1.24

0.380

–

Extracellular (SPI)

isaA

Putative transglycosylase IsaA

ACAKHAOO_00631

5

2

1.18

0.213

–

Extracellular (SPI)

–

Hypothetical protein

ACAKHAOO_02587

2

2

1.06

0.815

–

Extracellular (SPI)

isaB

Immunodominant staphylococcal antigen B

ACAKHAOO_00744

2

2

1.01

0.916

–

Membrane (SPI)

dtpT

Di-tripepride ABC transporter

ACAKHAOO_02598

8

5

−1.01

0.997

–

Surfacea(SPII)

proX

ABC transporter substrate-binding protein / Glycine betaine/carnitine transport binding protein GbuC

ACAKHAOO_02593

81

28

−1.01

0.936

LPNTG

Cell Wall (SPI)

–

Cell wall anchor protein / hypothetical protein

ACAKHAOO_01810

3

3

−1.02

0.960

–

Membrane (SPI)

yhaN

Putative protein YhaN

ACAKHAOO_01224

2

2

−1.04

0.907

–

Membrane (SPI)

rseP

Putative zinc metalloprotease

ACAKHAOO_02549

5

3

−1.05

0.766

–

Membrane (SPI)

brpA

Polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase TagU / transcriptional regulator

ACAKHAOO_01770

2

2

−1.06

0.763

–

Extracellular (SPI)

lytD

Bifunctional autolysin

ACAKHAOO_01453

7

3

−1.07

0.734

–

Extracellular (SPI)

lapA

Extracellular matrix-binding protein ebh / YSIRK-type signal peptide-containing protein

ACAKHAOO_01492

13

5

−1.07

0.915

–

Surfacea(Possibly sec)

ebpS

Elastin-binding protein EbpS

ACAKHAOO_01541

2

2

−1.09

0.689

–

Membrane (SPI)

yqhL

Putative protein YibN / sulfurtransferase

ACAKHAOO_00323

5

4

−1.09

0.573

–

Membrane (SPI)

ykuT

Small-conductance mechanosensitive channel

ACAKHAOO_01042

4

2

−1.10

0.582

–

Membrane (SPII)

cyoA

Putative quinol oxidase subunit 2

ACAKHAOO_02168

8

5

−1.10

0.528

–

Membrane (SPI)

cusA

Swarming motility protein SwrC

ACAKHAOO_01077

3

3

−1.10

0.596

–

Extracellular (SPII)

recN

Cell-wall vinding protein / hypothetical protein

ACAKHAOO_01640

2

2

−1.11

0.230

–

Membrane (SPI)

secF

Protein translocase subunit SecDF

ACAKHAOO_01808

9

5

−1.12

0.545

–

Membrane (SPII)

prsA

Foldase protein PrsA

ACAKHAOO_00719

2

1

−1.14

0.487

–

Membrane (SPII)

corC1

UPF0053 protein / HlyC/CorC family transporter

ACAKHAOO_02236

3

1

−1.14

0.633

–

Membrane (SPI)

lyrA

Lysostaphin resistance protein A

ACAKHAOO_01582

14

7

−1.16

0.360

–

Membrane (SPI)

yqfA

UPF0365 protein / hypothetical protein

ACAKHAOO_01462

6

6

−1.17

0.399

–

Membrane (SPI)

ponA

Penicillin-binding protein

ACAKHAOO_01561

3

3

−1.17

0.634

–

Extracellular (No pathway)

sodA

Superoxide dismutase [Mn/Fe]

ACAKHAOO_01806

5

3

−1.18

0.235

–

Extracellular (SPI)

yhaH

Hypothetical protein

ACAKHAOO_00464

28

12

−1.19

0.327

–

Membrane (SPI)

ftsH

ATP-dependent zinc metalloprotease FtsH

ACAKHAOO_01734

49

8

−1.19

0.394

–

Surfacea(SpI)

ytxG

DUF948 domain-containing protein

ACAKHAOO_02191

7

6

−1.20

0.452

–

Membrane (SPII)

fhuD

Ferrichrome ABC transporter substrate-binding protein

ACAKHAOO_01088

5

1

−1.20

0.591

–

Membrane (SPI)

–

DUF4064 hypothetical protein

ACAKHAOO_01722

15

8

−1.21

0.377

–

Membrane (SPI)

htrA

Serine protease Do-like HtrA/HtrB

ACAKHAOO_02068

2

2

−1.21

0.607

–

Membrane (SPI)

–

Hypothetical protein

ACAKHAOO_01403

2

1

−1.21

0.660

–

Surfacea(No pathway)

pstB

Phosphate import ATP-binding protein PstB 3

ACAKHAOO_00958

5

4

−1.22

0.357

–

Membrane (SPI)

spsB

Signal peptidase IB

ACAKHAOO_00494

2

2

−1.23

0.243

–

Membrane (SPI)

yacL

Putative PIN and TRAM-domain containing protein YacL

ACAKHAOO_02026

2

1

−1.23

0.314

–

Membrane (SPI)

atpF

ATP synthase subunit b

ACAKHAOO_01924

10

3

−1.24

0.066

–

Membrane (SPI)

–

Hypothetical protein

ACAKHAOO_01062

3

1

−1.25

0.454

–

Extracellular (No pathway)

–

Hypothetical protein

ACAKHAOO_00182

40

16

−1.28

0.265

–

Membrane (SPII)

sitA

Metal ABC transporter substrate-binding protein / Manganese-binding lipoprotein MntA

ACAKHAOO_01347

8

5

−1.29

0.151

–

Surfacea(SpI)

–

Hypothetical protein

ACAKHAOO_00718

4

3

−1.31

0.223

–

Membrane (SPI)

fruA

PTS system fructose-specific EIIABC component

ACAKHAOO_00753

25

10

−1.32

0.226

–

Surfacea(SPII)

fatB

Putative ABC transporter solute-binding protein YclQ

ACAKHAOO_01747

12

6

−1.34

0.096

–

Surfacea(SpI)

–

Hypothetical protein

ACAKHAOO_00561

8

7

−1.34

0.209

–

Membrane (No pathway)

murF

Capsule biosynthesis protein CapA

ACAKHAOO_02597

8

7

−1.35

0.204

–

Membrane (SPI)

ydfJ

Membrane protein YdfJ

ACAKHAOO_01736

2

2

−1.38

0.169

–

Surfacea(No pathway)

sftA

DNA translocase FtsK/SftA

ACAKHAOO_02099

2

2

−1.38

0.121

–

Membrane (SPII)

fecB

Iron citrate ABC transporter substrate-binding protein YfmC

ACAKHAOO_00362

6

5

−1.39

0.108

–

Membrane (SPII)

penP

Beta-lactamase

ACAKHAOO_00976

9

5

−1.40

0.051

–

Extracellular (SPII)

oppA

Oligopeptide ABC transporter / Dipeptide-binding protein DppE

ACAKHAOO_00003

25

7

−1.41

0.500

LPMTG

Cell Wall (SPI)

 

Hypothetical protein

ACAKHAOO_01406

17

7

−1.42

0.107

–

Membrane (SPII)

pstS

Phosphate-binding protein PstS

ACAKHAOO_02108

18

7

−1.43

0.261

–

Membrane (SPI)

–

Hypothetical protein

ACAKHAOO_00974

3

3

−1.47

0.139

–

Membrane (No pathway)

oppD

ABC transporter / nickel transport system / Oligopeptide transport ATP-binding protein OppD

ACAKHAOO_00701

11

4

−1.47

0.338

–

Surfacea(SpI)

–

Hypothetical protein

ACAKHAOO_00229

25

14

−1.49

0.130

–

Membrane (SPI)

pbpC

Beta-lactam-inducible penicillin-binding protein

ACAKHAOO_01885

2

1

−1.53

0.146

–

Membrane (SPI)

yihY

UPF0761 protein

ACAKHAOO_02197

5

2

−1.54

0.038

–

Extracellular (SPI)

ssaA

Staphylococcal secretory antigen SsaA / CHAP domain-containing protein

ACAKHAOO_01752

3

2

−1.67

0.102

LPNTG

Cell Wall (SPI)

–

Extracellular matrix-binding protein ebh / Signal peptide protein, YSIRK family / DUF1542

ACAKHAOO_00904

9

4

−1.74

0.026

–

Surfacea(SPII)

metQ

Methionine-binding lipoprotein MetQ

  1. Surface proteins were defined as proteins predicted from cytoplasmic membrane, cell wall or extracellular origin. Positive prediction of subcellular localization was determined by a two out of three or greater concurrent results between the databases
  2. aSurface: proteins were predicted as from cytoplasmic membrane, cell wall or extracellular origin, however, concurrent results between two out of three databases were not obtained