Skip to main content

Table 3 Evaluation of select drug candidates against B. henselae biofilm-recovered cells after drug exposure at different times

From: Effect of different drugs and drug combinations on killing stationary phase and biofilms recovered cells of Bartonella henselae in vitro

Drugs (5 μg/ml)CFU per mL after drug exposure
2 day4 day6 day
Drug free control1.3 ± 0.2 × 10101.8 ± 0.2 × 10102.6 ± 0.3 × 1010
Azithromycin4.5 ± 0.3 × 1095.2 ± 0.3 × 1099.3 ± 0.2 × 105
Cefuroxime5.6 ± 0.3 × 1092.3 ± 0.2 × 1091.7 ± 0.1 × 106
Ciprofloxacin3.2 ± 0.3 × 1082.5 ± 0.3 × 1085.1 ± 0.3 × 102
Daptomycin9.8 ± 0.2 × 1093.4 ± 0.3 × 1092.7 ± 0.2 × 106
Disulfiram6.1 ± 0.3 × 1094.6 ± 0.3 × 1093.8 ± 0.3 × 107
Doxycycline5.3 ± 0.3 × 1093.8 ± 0.1 × 1096.2 ± 0.3 × 105
Gentamicin6.2 ± 0.3 × 1095.8 ± 0.2 × 1098.1 ± 0.3 × 102
Methylene blue8.9 ± 0.4 × 1096.8 ± 0.2 × 1092.3 ± 0.2 × 102
Miconazole9.8 ± 0.3 × 1092.2 ± 0.1 × 10101.6 ± 0.1 × 1010
Nitrofurantoin4.3 ± 0.1 × 1093.6 ± 0.2 × 1092.8 ± 0.2 × 109
Rifampin5.6 ± 0.2 × 1094.8 ± 0.3 × 1093.2 ± 0.2 × 102
SXT7.8 ± 0.3 × 1096.4 ± 0.3 × 1092.7 ± 0.2 × 109
Azithromycin+Ciprofloxacin4.1 ± 0.2 × 1095.8 ± 0.3 × 1060
Azithromycin+Methylene blue6.8 ± 0.2 × 1095.2 ± 0.3 × 1050
Rifampin+Ciprofloxacin7.6 ± 0.2 × 1094.7 ± 0.2 × 1090
Rifampin+Methylene blue5.9 ± 0.1 × 1094.8 ± 0.2 × 1090