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Table 5 Regression statistics and analysis of variance (ANOVA) for Box-Behnken design results

From: Identification of cholesterol-assimilating actinomycetes strain and application of statistical modeling approaches for improvement of cholesterol oxidase production by Streptomyces anulatus strain NEAE-94

Source

df

Coefficient estimate

F-value

P-value Prob > F

Model

9

26.55

113.82

<  0.0001*

X1

1

0.04

0.02

0.9071

X2

1

3.18

119.05

0.0001*

X3

1

0.35

1.48

0.2782

X1 X2

1

1.15

7.80

0.0383*

X1 X3

1

−3.25

62.24

0.0005*

X2 X3

1

1.15

7.80

0.0383*

X12

1

−7.69

321.59

<  0.0001*

X22

1

−3.82

79.45

0.0003*

X32

1

−9.84

526.73

<  0.0001*

R2

0.9951

Std. Dev.

0.82

 

Adj R2

0.9864

Mean

15.16

 

Pred R2

0.9427

C.V. %

5.44

 

Adeq Precision

31.469

PRESS

40.03

 
  1. * Significant values, “df: Degree of freedom, F: Fishers’s function, P: Level of significance, C.V: Coefficient of variation”