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Table 3 Cox proportional hazard ratios for common S. maltophilia and strain-specific genes

From: Identification and characterization of differentially expressed genes in Caenorhabditis elegans in response to pathogenic and nonpathogenic Stenotrophomonas maltophilia

       Relative to wildtype
Nematode Bacteria N M SE Hazard Ratio
exp(β)
p value
  wildtype OP50 516 10.59 0.23 NA  
  K279a 615 10.87 0.19 NA  
  JCMS 608 5.44 0.07 NA  
  JV3 580 2.53 0.03 NA  
CPSR genes B0024.4 OP50 26 10.50 0.78 0.88 0.698
(mh82) K279a 58 8.66 0.55 1.32 0.146
  JCMS 90 4.74 0.16 1.28 0.14
  JV3 58 2.06 0.07 1.54 .03*
F08G2.5 OP50 46 10.43 0.77 0.99 0.988
(mh86) K279a 59 10.85 0.68 1.03 0.897
  JCMS 57 5.39 0.23 1.10 0.696
  JV3 59 2.72 0.07 0.91 0.68
ZK6.11 OP50 46 12.24 0.74 0.76 0.194
(ok3738) K279a 57 10.39 0.62 1.12 0.636
  JCMS 58 4.47 0.14 2.19 1.33E-6*
  JV3 56 2.27 0.08 1.41 0.07
T24B8.5 OP50 58 10.69 0.60 1.04 0.897
(ok3236) K279a 61 10.20 0.60 0.97 0.923
  JCMS 60 4.88 0.16 1.41 0.053
  JV3 57 1.94 0.07 2.23 8.9E-7*
dod-19 OP50 56 11.84 0.64 0.76 0.14
(ok2679) K279a 60 9.80 0.57 1.13 0.577
  JCMS 60 4.07 0.12 0.36 7.27E-11*
  JV3 58 2.36 0.10 1.04 0.873
dod-22 OP50 74 10.22 0.54 1.23 0.216
(ok1918) K279a 90 13.23 0.41 0.83 0.216
  JCMS 89 5.87 0.18 1.07 0.702
  JV3 89 0.28 0.08 0.82 0.194
K08D8.4 OP50 79 10.95 0.66 0.92 0.696
(mh101) K279a 90 7.62 0.50 2.11 1.46E-8*
  JCMS 87 4.82 0.17 1.68 .000154*
  JV3 85 2.36 0.08 1.37 .038*
lys-1 OP50 82 10.09 0.42 1.46 .010*
(ok2445) K279a 90 9.17 0.44 1.67 .000147*
  JCMS 88 4.76 0.14 1.92 1.33E-6*
  JV3 86 2.77 0.08 0.78 0.129
clec-67 OP50 79 11.56 0.53 0.92 0.681
(ok2770) K279a 55 13.20 0.68 0.71 0.077
  JCMS 57 5.46 0.24 1.06 0.8
  JV3 53 2.67 0.10 1.00 0.988
lys-2 OP50 85 10.44 0.50 1.04 0.853
(tm2398) K279a 58 10.21 0.54 1.36 0.077
  JCMS 58 5.71 0.19 0.92 0.698
  JV3 55 2.59 0.08 1.13 0.606
F55G11.8 OP50 59 10.51 0.61 0.89 0.601
(gk3130) K279a 58 11.55 0.51 0.79 0.216
  JCMS 60 5.65 0.19 0.80 0.217
  JV3 57 2.44 0.10 0.92 0.698
scl-2 OP50 51 15.43 0.73 0.49 2.97E-5*
(tm2428) K279a 54 11.72 0.64 0.85 0.45
  JCMS 56 5.75 0.17 1.00 0.988
  JV3 55 2.42 0.12 1.24 0.268
VSR genes acdh-1 OP50 50 7.12 0.77 1.68 .00688*
(ok1489) K279a 59 8.53 0.49 1.74 .00178*
  JCMS 58 4.59 0.19 1.68 .00427*
  JV3 58 2.68 0.11 0.62 .008*
sodh-1 OP50 53 10.55 0.64 1.09 0.698
(ok2799) K279a 54 9.48 0.56 1.41 0.065
  JCMS 56 4.71 0.15 1.7 .00164*
  JV3 55 2.5 0.11 0.97 0.897
pho-1 OP50 54 12.11 0.69 0.78 0.211
(tm5302) K279a 55 12.47 0.74 0.68 .0405*
  JCMS 55 4.58 0.18 2.22 1.33E-6*
  JV3 60 2.33 0.11 1.36 0.088
C55A6.7 OP50 57 11.91 0.69 0.80 0.234
(tm6807) K279a 59 13.51 0.75 0.52 4.71E-5*
  JCMS 59 5.39 0.15 1.13 0.6
  JV3 57 2.4 0.07 1.37 0.077
acox-1.4 OP50 58 9.91 0.42 1.53 .0137*
(tm6415) K279a 60 6.2 0.33 4.10 <2E-16*
  JCMS 57 4.63 0.17 2.02 1.47E-5*
  JV3 55 2.03 0.08 2.53 1.38E-8*
dhs-3 OP50 55 12 0.67 1.20 0.37
(tm6151) K279a 58 9.16 0.65 1.95 4.45E-5*
  JCMS 55 4.87 0.15 2.41 4.04E-8*
  JV3 55 2.04 0.08 2.97 2.31E-9*
F13D12.6 OP50 53 11.92 0.64 0.75 0.146
(tm7051) K279a 58 10.98 0.51 1.01 0.216
  JCMS 56 6 0.15 0.82 0.32
  JV3 57 2.59 0.12 0.88 0.566
dhs-2 OP50 27 9.3 0.80 1.24 0.474
(tm7516) K279a 53 7.72 0.43 1.78 .00095*
  JCMS 53 4.91 0.20 1.11 0.681
  JV3 53 1.64 0.09 2.74 2.35E-11*
JSR genes nhr-110 OP50 30 14.23 0.77 0.52 .00427*
(gk987) K279a 58 9.69 0.57 0.95 0.853
  JCMS 58 5.16 0.13 1.06 0.8
  JV3 57 2.29 0.07 1.13 0.619
W02A2.8 OP50 59 11.27 0.56 0.98 0.929
(mh87) K279a 59 10.42 0.65 1.00 0.988
  JCMS 59 5.22 0.17 1.29 0.15
  JV3 57 2.35 0.1 1.31 0.14
  1. Mean survival (M), standard error of the mean (SE), and sample size (N), are given for each nematode genotype and bacterial treatment combination. Wild-type statistics were determined from combining all wild-type data from all experiments. Hazard ratios (natural log(β)) indicate the treatment hazard divided by the hazard of wild-type (first column) across all experiments. The hazard is defined as the probability of a nematode dying at a given time. Hazard ratios and associated FDR adjusted p-values for each comparison were determined using Cox proportional hazards mixed effects model and general linear hypothesis tests and applying the Benjamini-Hochberg procedure to adjust for multiple comparisons in R. Asterisk indicate significant p-values (p<0.05)