Skip to main content

Table 3 Cox proportional hazard ratios for common S. maltophilia and strain-specific genes

From: Identification and characterization of differentially expressed genes in Caenorhabditis elegans in response to pathogenic and nonpathogenic Stenotrophomonas maltophilia

      

Relative to wildtype

Nematode

Bacteria

N

M

SE

Hazard Ratio

exp(β)

p value

 

wildtype

OP50

516

10.59

0.23

NA

 
 

K279a

615

10.87

0.19

NA

 
 

JCMS

608

5.44

0.07

NA

 
 

JV3

580

2.53

0.03

NA

 

CPSR genes

B0024.4

OP50

26

10.50

0.78

0.88

0.698

(mh82)

K279a

58

8.66

0.55

1.32

0.146

 

JCMS

90

4.74

0.16

1.28

0.14

 

JV3

58

2.06

0.07

1.54

.03*

F08G2.5

OP50

46

10.43

0.77

0.99

0.988

(mh86)

K279a

59

10.85

0.68

1.03

0.897

 

JCMS

57

5.39

0.23

1.10

0.696

 

JV3

59

2.72

0.07

0.91

0.68

ZK6.11

OP50

46

12.24

0.74

0.76

0.194

(ok3738)

K279a

57

10.39

0.62

1.12

0.636

 

JCMS

58

4.47

0.14

2.19

1.33E-6*

 

JV3

56

2.27

0.08

1.41

0.07

T24B8.5

OP50

58

10.69

0.60

1.04

0.897

(ok3236)

K279a

61

10.20

0.60

0.97

0.923

 

JCMS

60

4.88

0.16

1.41

0.053

 

JV3

57

1.94

0.07

2.23

8.9E-7*

dod-19

OP50

56

11.84

0.64

0.76

0.14

(ok2679)

K279a

60

9.80

0.57

1.13

0.577

 

JCMS

60

4.07

0.12

0.36

7.27E-11*

 

JV3

58

2.36

0.10

1.04

0.873

dod-22

OP50

74

10.22

0.54

1.23

0.216

(ok1918)

K279a

90

13.23

0.41

0.83

0.216

 

JCMS

89

5.87

0.18

1.07

0.702

 

JV3

89

0.28

0.08

0.82

0.194

K08D8.4

OP50

79

10.95

0.66

0.92

0.696

(mh101)

K279a

90

7.62

0.50

2.11

1.46E-8*

 

JCMS

87

4.82

0.17

1.68

.000154*

 

JV3

85

2.36

0.08

1.37

.038*

lys-1

OP50

82

10.09

0.42

1.46

.010*

(ok2445)

K279a

90

9.17

0.44

1.67

.000147*

 

JCMS

88

4.76

0.14

1.92

1.33E-6*

 

JV3

86

2.77

0.08

0.78

0.129

clec-67

OP50

79

11.56

0.53

0.92

0.681

(ok2770)

K279a

55

13.20

0.68

0.71

0.077

 

JCMS

57

5.46

0.24

1.06

0.8

 

JV3

53

2.67

0.10

1.00

0.988

lys-2

OP50

85

10.44

0.50

1.04

0.853

(tm2398)

K279a

58

10.21

0.54

1.36

0.077

 

JCMS

58

5.71

0.19

0.92

0.698

 

JV3

55

2.59

0.08

1.13

0.606

F55G11.8

OP50

59

10.51

0.61

0.89

0.601

(gk3130)

K279a

58

11.55

0.51

0.79

0.216

 

JCMS

60

5.65

0.19

0.80

0.217

 

JV3

57

2.44

0.10

0.92

0.698

scl-2

OP50

51

15.43

0.73

0.49

2.97E-5*

(tm2428)

K279a

54

11.72

0.64

0.85

0.45

 

JCMS

56

5.75

0.17

1.00

0.988

 

JV3

55

2.42

0.12

1.24

0.268

VSR genes

acdh-1

OP50

50

7.12

0.77

1.68

.00688*

(ok1489)

K279a

59

8.53

0.49

1.74

.00178*

 

JCMS

58

4.59

0.19

1.68

.00427*

 

JV3

58

2.68

0.11

0.62

.008*

sodh-1

OP50

53

10.55

0.64

1.09

0.698

(ok2799)

K279a

54

9.48

0.56

1.41

0.065

 

JCMS

56

4.71

0.15

1.7

.00164*

 

JV3

55

2.5

0.11

0.97

0.897

pho-1

OP50

54

12.11

0.69

0.78

0.211

(tm5302)

K279a

55

12.47

0.74

0.68

.0405*

 

JCMS

55

4.58

0.18

2.22

1.33E-6*

 

JV3

60

2.33

0.11

1.36

0.088

C55A6.7

OP50

57

11.91

0.69

0.80

0.234

(tm6807)

K279a

59

13.51

0.75

0.52

4.71E-5*

 

JCMS

59

5.39

0.15

1.13

0.6

 

JV3

57

2.4

0.07

1.37

0.077

acox-1.4

OP50

58

9.91

0.42

1.53

.0137*

(tm6415)

K279a

60

6.2

0.33

4.10

<2E-16*

 

JCMS

57

4.63

0.17

2.02

1.47E-5*

 

JV3

55

2.03

0.08

2.53

1.38E-8*

dhs-3

OP50

55

12

0.67

1.20

0.37

(tm6151)

K279a

58

9.16

0.65

1.95

4.45E-5*

 

JCMS

55

4.87

0.15

2.41

4.04E-8*

 

JV3

55

2.04

0.08

2.97

2.31E-9*

F13D12.6

OP50

53

11.92

0.64

0.75

0.146

(tm7051)

K279a

58

10.98

0.51

1.01

0.216

 

JCMS

56

6

0.15

0.82

0.32

 

JV3

57

2.59

0.12

0.88

0.566

dhs-2

OP50

27

9.3

0.80

1.24

0.474

(tm7516)

K279a

53

7.72

0.43

1.78

.00095*

 

JCMS

53

4.91

0.20

1.11

0.681

 

JV3

53

1.64

0.09

2.74

2.35E-11*

JSR genes

nhr-110

OP50

30

14.23

0.77

0.52

.00427*

(gk987)

K279a

58

9.69

0.57

0.95

0.853

 

JCMS

58

5.16

0.13

1.06

0.8

 

JV3

57

2.29

0.07

1.13

0.619

W02A2.8

OP50

59

11.27

0.56

0.98

0.929

(mh87)

K279a

59

10.42

0.65

1.00

0.988

 

JCMS

59

5.22

0.17

1.29

0.15

 

JV3

57

2.35

0.1

1.31

0.14

  1. Mean survival (M), standard error of the mean (SE), and sample size (N), are given for each nematode genotype and bacterial treatment combination. Wild-type statistics were determined from combining all wild-type data from all experiments. Hazard ratios (natural log(β)) indicate the treatment hazard divided by the hazard of wild-type (first column) across all experiments. The hazard is defined as the probability of a nematode dying at a given time. Hazard ratios and associated FDR adjusted p-values for each comparison were determined using Cox proportional hazards mixed effects model and general linear hypothesis tests and applying the Benjamini-Hochberg procedure to adjust for multiple comparisons in R. Asterisk indicate significant p-values (p<0.05)
Back to article page

BMC Microbiology

ISSN: 1471-2180

Contact us