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Table 2 Significant correlation of colonic metabolite-correlated microbial taxa and DNA methylation-related differential gene expression (n = 4)

From: Multi-omic profiling reveals associations between the gut mucosal microbiome, the metabolome, and host DNA methylation associated gene expression in patients with colorectal cancer

Microbial taxa Genes Coding protein r valuea p-value
Genus Fusobacterium
(increased in tumour)
PI16
(decreased in tumour)
Peptidase inhibitor 16 −0.993 0.008
  FCRLA
(decreased in tumour)
Fc Receptor Like A 0.956 0.044
  LSP1
(decreased in tumour)
Lymphocyte Specific Protein 1 0.954 0.046
Genus Prevotella 2
(increased in tumour)
MT1M
(decreased in tumour)
Metallothionein −0.999 0.001
Family Halomonadaceae
(increased in tumour)
RELN
(decreased in tumour)
Reelin 0.957 0.043
Genus Paeniclostridium
(decreased in tumour)
PLCB1
(increased in tumour)
Phospholipase C beta 1 0.995 0.010
Genus Enterococcus
(decreased in tumour)
IGSF9
(decreased in tumour)
Immunoglobulin Superfamily Member 9 −0.997 0.003
  1. aFor the calculation of the correlations, the signed relative change of microbe abundance and gene expression level between paired tumour and normal tissues were used