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Table 2 Significant correlation of colonic metabolite-correlated microbial taxa and DNA methylation-related differential gene expression (n = 4)

From: Multi-omic profiling reveals associations between the gut mucosal microbiome, the metabolome, and host DNA methylation associated gene expression in patients with colorectal cancer

Microbial taxa

Genes

Coding protein

r valuea

p-value

Genus Fusobacterium

(increased in tumour)

PI16

(decreased in tumour)

Peptidase inhibitor 16

−0.993

0.008

 

FCRLA

(decreased in tumour)

Fc Receptor Like A

0.956

0.044

 

LSP1

(decreased in tumour)

Lymphocyte Specific Protein 1

0.954

0.046

Genus Prevotella 2

(increased in tumour)

MT1M

(decreased in tumour)

Metallothionein

−0.999

0.001

Family Halomonadaceae

(increased in tumour)

RELN

(decreased in tumour)

Reelin

0.957

0.043

Genus Paeniclostridium

(decreased in tumour)

PLCB1

(increased in tumour)

Phospholipase C beta 1

0.995

0.010

Genus Enterococcus

(decreased in tumour)

IGSF9

(decreased in tumour)

Immunoglobulin Superfamily Member 9

−0.997

0.003

  1. aFor the calculation of the correlations, the signed relative change of microbe abundance and gene expression level between paired tumour and normal tissues were used