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Fig. 4 | BMC Microbiology

Fig. 4

From: Multi-omic profiling reveals associations between the gut mucosal microbiome, the metabolome, and host DNA methylation associated gene expression in patients with colorectal cancer

Fig. 4

Comparison of the mucosal transcriptome and DNA methylation profile between tumour tissues and normal tissues a. MDS plot of transcriptome between tissue samples. Each point represents one sample with colour indicating tumour tissues (red) and adjacent normal tissues (blue), shape indicating the patient. b. Volcano plot of the significant differences in the mucosal transcriptome between paired samples. The x-axis shows the gene expression log2FC between paired samples; the y-axis represents minus log10(FDR-adjusted p-value) calculated from GLM. Genes with more than two fold change in expression level are coloured in red (upregulated in tumour tissues) and green (downregulated in tumour tissues). c. MDS plot of DNA methylation for differentially expressed genes between paired tissue samples. Each point represents one sample with colour indicating tumour tissues (red) and adjacent normal tissues (blue), shape indicating the patient. d. Heatmap visualizing the DNA methylation related differentially expressed genes between tumour (red) and normal tissues (blue) based on hierarchical clustering analysis. The rows demonstrate the genes and the columns display samples

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BMC Microbiology

ISSN: 1471-2180

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