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Table 2 Allelic and amino acid difference in genes involved in apoptosis, iron acquisition, and LOS between Neisseriameningitidis serogroup W and Y isolates

From: Difference in virulence between Neisseria meningitidis serogroups W and Y in transgenic mice

LocusGene nameGene productFunctionAllele Serogroup Y (frequency)Allele Serogroup W (frequency)Difference in amino acids between serogroups W and YFrequency of alleles in isolates in PubMLST
NEIS2020porBPorin, major outer membrane proteinInflammatory response/ induction of apoptosis67 (8/10)244 (12/13)142 aaY: 37%
W: 47%
NEIS0651igaIgA1 proteaseInflammatory response/ induction of apoptosis189 (9/10)37 (10/13)72 aaY: 60%
W: 74%
NEIS0414ponAPenicillin-binding protein 1Inflammatory response/ induction of apoptosis45 (9/10)1 (10/13)2 aaY: 71%
W: 95%
NEIS1753penAPenicillin-binding protein 2Inflammatory response/ induction of apoptosis8 (10/10)59 (11/13)0 aaY: 70%
W: 74%
NEIS1468lbpALactoferrin binding protein AIron acquisition226 (9/10)8 (9/13)33 aaY: 51%
W: 82%
NEIS1469lbpBLactoferrin binding protein BIron acquisition137 (9/10)5 (7/13)155 aaY: 52%
W: 49%
NEIS1690tbpATransferrin binding protein AIron acquisition1054 (3/10)2 (11/13)221 aaY: 3.8%
W: 89%
NEIS1691tbpBTransferrin binding protein BIron acquisition1111 (3/10)1 (12/13)441 aaY: 1.4%
W: 81%
NEIS1946hpuAHaemoglobin-haptoglobin utilisation proteinIron acquisition110 (4/10)776 (3/13) Absent (9/13)70 aaY: 44%
W: 52% (Absent), 13% (776)
NEIS1947hpuBHaemoglobin-haptoglobin utilisation proteinIron acquisition35 (10/10)1898 (9/13)39 aaY: 67%
W: 32%
hmbRhmbRHaemoglobin receptor proteinIron acquisitionAbsent (10/10)8 (6/13) 9 (6/13)N/AY: 98%
W: 21% (8), 46% (9)
NEIS0304mshALipid A export ATP-binding/permease protein (IM)LOS118 (9/10)89 (12/13)2 aaY: 82%
W: 28%
NEIS0657rlpB LOS3 (9/10)1 (12/13)0 aaY: 75%
W: 95%
NEIS1456rfaFHeptosyltransferase IILOS22 (10/10)4 (13/13)6 aaY: 77%
W: 71%
NEIS1618lgtFBeta-1,4 glucosyltransferaseLOS57 (9/10)43 (13/13)2 aaY: 70%
W: 80%
NEIS1619rfaKAlpha-1,2 N-acetylglucosamine transferaseLOS31 (10/10)92 (12/13)12 aaY: 77%
W: 52%
NEIS1812yhbGLipopolysaccharide ABC transporterLOS107 (6/10)1 (12/13)12 aaY: 9.4%
W: 88%
NEIS1814lptCLipopolysaccharide export system protein (OM)LOS2 (10/10)1 (12/13)3 aaY: 89%
W: 86%
NEIS1900lgtELacto-N-neotetraose biosynthesis glycosyl transferaseLOS162;206 (6/10)45;321 (13/13)101 aaY: 40%
W: 52%
NEIS1901lgtBLacto-N-neotetraose biosynthesis glycosyl transferaseLOS81 (6/10)79 (13/13)10 aaY: 61%
W: 56%
NEIS1986lpt3LOS O-3 PEA transferaseLOS38 (1/10) Absent (9/10)4 (12/13)13 aaY: 7.7% (38), 51% (Absent)
W: 80%
NEIS2012lpt6O-6 PEA LOS transferaseLOSAbsent (10/10)3 (13/13)N/AY: 96%
W: 84%
NEIS2134rfaCHeptosyltransferase ILOS3 (10/10)1 (13/13)17 aaY: 82%
W: 60%
  1. aa Amino acids
  2. N/A Not applicable
  3. LOS Lipooligosaccharide
  4. W Neisseria meningitidis Serogroup W
  5. Y Neisseria meningitidis Serogroup Y