Table 2 Allelic and amino acid difference in genes involved in apoptosis, iron acquisition, and LOS between Neisseriameningitidis serogroup W and Y isolates
From: Difference in virulence between Neisseria meningitidis serogroups W and Y in transgenic mice
Locus | Gene name | Gene product | Function | Allele Serogroup Y (frequency) | Allele Serogroup W (frequency) | Difference in amino acids between serogroups W and Y | Frequency of alleles in isolates in PubMLST |
|---|---|---|---|---|---|---|---|
NEIS2020 | porB | Porin, major outer membrane protein | Inflammatory response/ induction of apoptosis | 67 (8/10) | 244 (12/13) | 142 aa | Y: 37% W: 47% |
NEIS0651 | iga | IgA1 protease | Inflammatory response/ induction of apoptosis | 189 (9/10) | 37 (10/13) | 72 aa | Y: 60% W: 74% |
NEIS0414 | ponA | Penicillin-binding protein 1 | Inflammatory response/ induction of apoptosis | 45 (9/10) | 1 (10/13) | 2 aa | Y: 71% W: 95% |
NEIS1753 | penA | Penicillin-binding protein 2 | Inflammatory response/ induction of apoptosis | 8 (10/10) | 59 (11/13) | 0 aa | Y: 70% W: 74% |
NEIS1468 | lbpA | Lactoferrin binding protein A | Iron acquisition | 226 (9/10) | 8 (9/13) | 33 aa | Y: 51% W: 82% |
NEIS1469 | lbpB | Lactoferrin binding protein B | Iron acquisition | 137 (9/10) | 5 (7/13) | 155 aa | Y: 52% W: 49% |
NEIS1690 | tbpA | Transferrin binding protein A | Iron acquisition | 1054 (3/10) | 2 (11/13) | 221 aa | Y: 3.8% W: 89% |
NEIS1691 | tbpB | Transferrin binding protein B | Iron acquisition | 1111 (3/10) | 1 (12/13) | 441 aa | Y: 1.4% W: 81% |
NEIS1946 | hpuA | Haemoglobin-haptoglobin utilisation protein | Iron acquisition | 110 (4/10) | 776 (3/13) Absent (9/13) | 70 aa | Y: 44% W: 52% (Absent), 13% (776) |
NEIS1947 | hpuB | Haemoglobin-haptoglobin utilisation protein | Iron acquisition | 35 (10/10) | 1898 (9/13) | 39 aa | Y: 67% W: 32% |
hmbR | hmbR | Haemoglobin receptor protein | Iron acquisition | Absent (10/10) | 8 (6/13) 9 (6/13) | N/A | Y: 98% W: 21% (8), 46% (9) |
NEIS0304 | mshA | Lipid A export ATP-binding/permease protein (IM) | LOS | 118 (9/10) | 89 (12/13) | 2 aa | Y: 82% W: 28% |
NEIS0657 | rlpB | LOS | 3 (9/10) | 1 (12/13) | 0 aa | Y: 75% W: 95% | |
NEIS1456 | rfaF | Heptosyltransferase II | LOS | 22 (10/10) | 4 (13/13) | 6 aa | Y: 77% W: 71% |
NEIS1618 | lgtF | Beta-1,4 glucosyltransferase | LOS | 57 (9/10) | 43 (13/13) | 2 aa | Y: 70% W: 80% |
NEIS1619 | rfaK | Alpha-1,2 N-acetylglucosamine transferase | LOS | 31 (10/10) | 92 (12/13) | 12 aa | Y: 77% W: 52% |
NEIS1812 | yhbG | Lipopolysaccharide ABC transporter | LOS | 107 (6/10) | 1 (12/13) | 12 aa | Y: 9.4% W: 88% |
NEIS1814 | lptC | Lipopolysaccharide export system protein (OM) | LOS | 2 (10/10) | 1 (12/13) | 3 aa | Y: 89% W: 86% |
NEIS1900 | lgtE | Lacto-N-neotetraose biosynthesis glycosyl transferase | LOS | 162;206 (6/10) | 45;321 (13/13) | 101 aa | Y: 40% W: 52% |
NEIS1901 | lgtB | Lacto-N-neotetraose biosynthesis glycosyl transferase | LOS | 81 (6/10) | 79 (13/13) | 10 aa | Y: 61% W: 56% |
NEIS1986 | lpt3 | LOS O-3 PEA transferase | LOS | 38 (1/10) Absent (9/10) | 4 (12/13) | 13 aa | Y: 7.7% (38), 51% (Absent) W: 80% |
NEIS2012 | lpt6 | O-6 PEA LOS transferase | LOS | Absent (10/10) | 3 (13/13) | N/A | Y: 96% W: 84% |
NEIS2134 | rfaC | Heptosyltransferase I | LOS | 3 (10/10) | 1 (13/13) | 17 aa | Y: 82% W: 60% |