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Fig. 5 | BMC Microbiology

Fig. 5

From: Vibiro vulnificus hemolysin associates with gangliosides

Fig. 5

Speculative cartoon representation of VVH toxic steps on cellular membrane. Step 1; Binding to ganglioside (GalĪ²1-3GalNAc) and to unknown molecule with GalĪ²1-3GalNAc at both cholesterol and glycan rich micro domain, and other membrane domain. Step 2; Interaction with cholesterol for oligomerization. Step 3; Conformational change to pore-form. Step 2 and 3 occurs at only cholesterol and glycan rich micro domain

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