Fig. 5
From: Vibiro vulnificus hemolysin associates with gangliosides
Speculative cartoon representation of VVH toxic steps on cellular membrane. Step 1; Binding to ganglioside (Galβ1-3GalNAc) and to unknown molecule with Galβ1-3GalNAc at both cholesterol and glycan rich micro domain, and other membrane domain. Step 2; Interaction with cholesterol for oligomerization. Step 3; Conformational change to pore-form. Step 2 and 3 occurs at only cholesterol and glycan rich micro domain