Table 2 Clinical and laboratory information for patients infected with C. gattii
1 | 2 | 4 | 5 | 6 | 7 | 8 | |
|---|---|---|---|---|---|---|---|
Location (Province) | Shangdong | Hainan | Fujian | Neimeng | Yunnan | Fujian | Henan |
isolation period of C. gattii | 2014.11 | 2015.12 | 2014.04 | 2016.06 | 2016.07 | 2015.09 | 2016.08 |
Gender | Male | Male | Male | Male | Male | Male | Male |
Age-ranges (years old) | 20–40 | 20–40 | 20–40 | 41–60 | 41–60 | 20–40 | 20–40 |
History (medical/contact) | No | No | No | No | No | No | No |
Immunity | Normal | Normal | Normal | Normal | Normal | Normal | Normal |
Fever | + | + | + | – | + | + | + |
Headache | + | + | + | + | + | + | – |
Nausea and Vomiting | – | + | + | + | – | – | – |
Seizure | – | – | + | – | – | – | – |
Neck stiffness | + | – | + | + | – | – | – |
Kernig’s sign | + | + | + | – | – | – | – |
Papilloedema | – | – | + | + | – | – | – |
Lung CT | Irregular nodule with spicules and lobulation | Left lower lung mass | Normal | Left lung mass | Left lower lung consolidation | Multiple small nodules | Right upper lung mass |
Brain MRI | Meningeal lesions | Normal | Meningeal enhancement | Left lacunar infarction | NA | Normal | Normal |
Organism also found by lung biopsy | Yes | NA | NA | NA | NA | Yes | Yes |
Blood culture | No growth | No growth | No growth | NA | NA | NA | No growth |
Cryptococcal antigen titre in serum | 1:1024 | NA | NA | NA | NA | NA | 1:640 |
CSF test: | |||||||
Pressure (mmH2O) | 260 | 330 | 330 | 330 | NA | 200 | normal |
Glucose (mmol/L) | 0.5 | 4.11 | 2.49 | 2.3 | NA | 2.22 | normal |
Protein (g/L) | 1.57 | 0.71 | 0.35 | 0.73 | NA | 29 | normal |
Chloride (mmol/L) | 111 | 144.7 | 117 | 102 | NA | 126.6 | normal |
White blood cells(×106cells/L) | 377 | 80 | 720 | 91 | NA | 368 | normal |
Ink staining | positive | positive | positive | positive | NA | NA | positive |
Cryptococcal antigen titre | 1:1024 | NA | NA | NA | NA | NA | 1:640 |
Organism cultured from | CSF | CSF | CSF | CSF/ | sputum | CSF | sputum |
Antifungal therapy regime | Flu+AmB | Flu+AmB | Flu+AmB | Flu+AmB | Flu+AmB | Flu+AmB | Flu+AmB |
Improvement (follow-up) | alive | alive | alive | alive | alive | alive | alive |
Neurological sequelae | No | No | Yes | No | No | No | No |