Table 3 The metabolites content (μg/g DCW) responsible for responding to fluconazole in Schizochytrium

 Oxalic acid

924.4 ± 22.7

557.3 ± 18.6*

1317.5 ± 114.3

597.8 ± 122.1*

575.9 ± 48.1

737.7 ± 33.3*

 Butanedioic acid

21.4 ± 7.1

24.1 ± 11.1

11.3 ± 1.6

10.9 ± 2.4

21.1 ± 6.6

18.1 ± 5.3

 Citric acid

22.6 ± 0.6

8.3 ± 1.1*

22.6 ± 9.9

13.6 ± 6.9*

26.9 ± 7.8

22.6 ± 8.3*

 Glucose

8503.2 ± 591.9

6838.7 ± 180.3*

654.1 ± 10.4

904.9 ± 18.4

154.2 ± 69.3

118.9 ± 48.3

 Glycerol

633.5 ± 82.5

469.4 ± 54.5*

351.3 ± 14.9

226.7 ± 27.8*

227.5 ± 17.8

399.7 ± 1111.9*

 Ethenal

75.7 ± 4.9

51.7 ± 9.8*

33.0 ± 0.7

25.3 ± 10.3*

163.3 ± 29.2

154.7 ± 31.5

 Phosphate acid

12,811.2 ± 324.3

8389.3 ± 701.5

4413.8 ± 511.0

4622.4 ± 119.0*

10,915.5 ± 2687.4

9960.5 ± 4480.4

 Glycine

74.9 ± 11.6

74.1 ± 11.1*

234.5 ± 23.8

148.5 ± 9.8*

147.4 ± 70.0

163.9 ± 63.2

 L-Serine

12.2 ± 3.2

10.1 ± 5.0

22.1 ± 1.1

18.6 ± 1.4*

4.4 ± 4.4

18.4 ± 8.2

 β-Alanine

0.1 ± 0.0

0.3 ± 0.0*

7.4 ± 0.8

9.0 ± 1.4*

17.1 ± 4.4

29.8 ± 8.6*

 Proline

225.0 ± 28.2

202.7 ± 22.8*

156.1 ± 55.1

322.9 ± 75.2*

427.1 ± 123.8

337.8 ± 40.7

 L-Glutamic acid

7.1 ± 0.4

8.2 ± 1.9

10.2 ± 1.6

6.3 ± 5.0*

9.4 ± 1.6

8.9 ± 1.5

 Phenylalanine

13.7 ± 0.7

29.0 ± 5.3*

10.8 ± 4.6

6.0 ± 4.5*

21.1 ± 2.6

14.6 ± 4.0

 Xylose

7.8 ± 1.0

5.6 ± 0.5*

10.6 ± 1.2

7.1 ± 11.4*

17.8 ± 3.5

22.5 ± 3.8

 Ribitol

30.7 ± 1.2

20.8 ± 2.9*

54.1 ± 0.5

44.7 ± 23.4*

18.1 ± 5.3

20.9 ± 3.0

 Trehalose

21.1 ± 7.7

11.9 ± 11.1*

42.6 ± 3.7

59.8 ± 6.1*

45.5 ± 5.0

69.2 ± 6.4

 Monostearate

23.5 ± 16.1

21.5 ± 10.5*

127.2 ± 18.5

239.5 ± 48.2*

155.9 ± 29.0

242.6 ± 31.0*

 Monopalmitin

17.7 ± 2.3*

17.6 ± 4.6

57.1 ± 9.0

83.2 ± 6.8*

268.0 ± 47.3

375.8 ± 60.3*

 Palmitic acid

1166.0 ± 77.5

889.9 ± 119.5

1712.2 ± 113.8

1262.7 ± 86.2*

1188.5 ± 151.0

1224.8 ± 246.0

 Stearic acid

1018.4 ± 107.2

648.4 ± 157.5*

593.5 ± 82.7

748.5 ± 72.6

703.9 ± 113.1

763.0 ± 109.9

 Arachidonic acid

19.9 ± 4.1

33.8 ± 4.6*

28.5 ± 2.5

36.3 ± 2.4*

41.9 ± 4.1

61.5 ± 15.2*

 Doconexent acid

237.5 ± 32.4

359.0 ± 26.9*

314.2 ± 33.6

267.0 ± 17.4

169.7 ± 31.5

271.5 ± 34.6*

 Squalene

510.2 ± 33.8

610.6 ± 80.0*

161.4 ± 5.8

63.1 ± 0.3*

88.6 ± 10.7

16.8 ± 8.5*

 Cholesterol

271.4 ± 40.9

202.9 ± 10.2*

246.8 ± 18.0

95.8 ± 2.9*

286.8 ± 28.3

254.2 ± 20.5

 Cyclo-ergosta

120.8 ± 6.3

111.6 ± 7.9*

194.5 ± 18.8

204.4 ± 12.0

198.2 ± 28.9

287.5 ± 80.2*

 β-Sitosterol

10.9 ± 2.5

47.8 ± 3.4*

86.3 ± 18.8

81.8 ± 4.7

51.1 ± 4.8

122.9 ± 32.4*

 Cholest-7-en-3-ol

8.2 ± 0.1

0.6 ± 0.3*

51.0 ± 4.5

6.0 ± 0.4*

48.2 ± 7.0

8.4 ± 2.0*

 Cholecalciferol

7.1 ± 0.4

2.2 ± 0.5*

30.5 ± 4.7

10.4 ± 0.3*

32.7 ± 9.7

16.1 ± 8.2*

 Stigmasterol

15.0 ± 6.4

353.7 ± 29.9*

14.7 ± 3.7

483.9 ± 9.9*

19.9 ± 13.8

638.1 ± 108.3*

 Lanosterol

47.0 ± 4.8

152.9 ± 2.9*

9.6 ± 0.7

37.9 ± 1.0*

9.2 ± 1.6

72.2 ± 25.7*

 Urea

2103.6 ± 183.8

1248.0 ± 130.2*

76.2 ± 4.2

32.9 ± 18.6*

71.4 ± 13.2

59.5 ± 19.9