Microbial biofilm correlates with an increased antibiotic tolerance and poor therapeutic outcome in infective endocarditis

Table 2 Microbiologic Tests for bacterial isolation, antibiotic therapy and biofilm production. The level of biofilm production was measured by the cBRT

Patients	Blood culture before surgery	Hearth valve culture	Hearth valve sonication	Antibiotic therapy	Biofilm production	Vegetation (Cm)
N1	Negative	Negative	S. aureus	Ceftriaxone; Piperacillin/Tazobactam	High	1.4
N2	MRSA	MRSA	MRSA	Linezolid; Piperacillin/Tazobactam	Moderate	1.2
N3	S. gallolyticus	Negative	S. gallolyticus	Ceftriaxone; Gentamicin	Moderate	1.6
N4	S. aureus	Negative	S. aureus	Vancomycin; Meropenem	High	1.5
N5	E. faecalis	Negative	E. faecalis	Piperacillin-Tazobactam; Ampicillin; Meropenem	High	2.1
N6	S. gallolyticus	Negative	S. gallolyticus	Piperacillin-Tazobactam; Vancomycin	High	2.2
N7	Negative	Negative	S. aureus	Ceftriaxone; Vancomycin; Piperacillin/Tazobactam	Moderate	1.3
N8	E. faecalis	Negative	E. faecalis	Vancomycin	High	1.8

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