Fig. 5

Regulatory role of RepR and RepR’ proteins in the initiation of pIGRK replication. Positive (+) and negative (−) effects, including the proposed mechanisms of RepR’ interference on the initiatory protein functioning, are indicated. The proposed binding sites of RepR and RepR’ within the REP module are indicated. The scheme does not account for how the proteins bind to individual elements of the REP module. The way of RepR and RepR’ binding (as monomers, or dimers) nor its possible cooperative character was considered