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Table 1 Antibiotics used in this study and their mechanism of action

From: Influence of antibiotic treatment on the detection of S. aureus in whole blood following pathogen enrichment

Antibiotic

Cell Wall Active

Mechanism of Action

Vancomycin (VAN)

+

interferes with cell wall synthesis by preventing formation and crosslinking of peptidoglycan strands [26,27,28]

Piperacillin (PIP)

+

interferes with cell wall synthesis by binding to enzymes required for the extracytoplasmatic stage of cell wall formation [28, 29]

Ciprofloxacin (CIP)

–

prevents replication of bacterial DNA by inhibiting DNA gyrase [30, 31]

Clindamycin (CLI)

–

inhibits bacterial protein synthesis by binding to 50S ribosomal subunits [32]