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Table 1 Antibiotics used in this study and their mechanism of action

From: Influence of antibiotic treatment on the detection of S. aureus in whole blood following pathogen enrichment

Antibiotic Cell Wall Active Mechanism of Action
Vancomycin (VAN) + interferes with cell wall synthesis by preventing formation and crosslinking of peptidoglycan strands [26,27,28]
Piperacillin (PIP) + interferes with cell wall synthesis by binding to enzymes required for the extracytoplasmatic stage of cell wall formation [28, 29]
Ciprofloxacin (CIP) prevents replication of bacterial DNA by inhibiting DNA gyrase [30, 31]
Clindamycin (CLI) inhibits bacterial protein synthesis by binding to 50S ribosomal subunits [32]