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Table 3 Pharmacokinetic and pharmacodynamic (PKPD) values for clarithromycin

From: Mutant selection window of clarithromycin for clinical isolates of Helicobacter pylori

  Dosage 2 × 200 mg Cmaxa = 0.36 AUC24 = 4.20
MICs Cmax/MIC90 Cmax/MPC90 AUC24/MIC90 AUC24/MPC90 T > MIC90 T > MPC90 TMSW
0.016 22.50 2.88 262.50 33.60 24 ~ 18 ~ 6
0.031 11.61 0.72 135.48 8.40 24 0 24
0.062–0.125 5.81 1.44 67.74 16.80 ~ 20 ~ 5 ~ 15
0.25 1.44 0.18 16.80 2.10 ~ 5 0 ~ 5
  Dosage 2 × 500 mg Cmaxb = 2.85 AUC24 = 41.72
  Cmax/MIC90 Cmax/MPC90 AUC24/MIC90 AUC24/MPC90 T > MIC90 T > MPC90 TMSW
0.016 178.13 22.80 2607.50 333.76 24 24 0
0.031 91.94 5.70 1345.81 83.44 24 ~ 20 ~ 4
0.062–0.125 45.97 11.40 672.90 166.88 24 ~ 22 ~ 2
0.25 11.40 1.43 166.88 20.86 ~ 22 ~ 5 ~ 17
  1. Cmax serum maximum concentration, AUC24 area under curve over a 24 h time period, TMSW time inside the mutant selection window (h). Concentrations are in mg/L
  2. aCmax was determined using a high-performance liquid chromatographic procedure and did not include 4-hydroxy-clarithromycin
  3. bCmax was determined using liquid chromatography tandem mass spectrometry and did not include 4-hydroxy-clarithromycin