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Table 3 Pharmacokinetic and pharmacodynamic (PKPD) values for clarithromycin

From: Mutant selection window of clarithromycin for clinical isolates of Helicobacter pylori

 

Dosage 2 × 200 mg Cmaxa = 0.36 AUC24 = 4.20

MICs

Cmax/MIC90

Cmax/MPC90

AUC24/MIC90

AUC24/MPC90

T > MIC90

T > MPC90

TMSW

0.016

22.50

2.88

262.50

33.60

24

~ 18

~ 6

0.031

11.61

0.72

135.48

8.40

24

0

24

0.062–0.125

5.81

1.44

67.74

16.80

~ 20

~ 5

~ 15

0.25

1.44

0.18

16.80

2.10

~ 5

0

~ 5

 

Dosage 2 × 500 mg Cmaxb = 2.85 AUC24 = 41.72

 

Cmax/MIC90

Cmax/MPC90

AUC24/MIC90

AUC24/MPC90

T > MIC90

T > MPC90

TMSW

0.016

178.13

22.80

2607.50

333.76

24

24

0

0.031

91.94

5.70

1345.81

83.44

24

~ 20

~ 4

0.062–0.125

45.97

11.40

672.90

166.88

24

~ 22

~ 2

0.25

11.40

1.43

166.88

20.86

~ 22

~ 5

~ 17

  1. Cmax serum maximum concentration, AUC24 area under curve over a 24 h time period, TMSW time inside the mutant selection window (h). Concentrations are in mg/L
  2. aCmax was determined using a high-performance liquid chromatographic procedure and did not include 4-hydroxy-clarithromycin
  3. bCmax was determined using liquid chromatography tandem mass spectrometry and did not include 4-hydroxy-clarithromycin