From: Mutant selection window of clarithromycin for clinical isolates of Helicobacter pylori
 | Dosage 2 × 200 mg Cmaxa = 0.36 AUC24 = 4.20 | ||||||
---|---|---|---|---|---|---|---|
MICs | Cmax/MIC90 | Cmax/MPC90 | AUC24/MIC90 | AUC24/MPC90 | T > MIC90 | T > MPC90 | TMSW |
0.016 | 22.50 | 2.88 | 262.50 | 33.60 | 24 | ~ 18 | ~ 6 |
0.031 | 11.61 | 0.72 | 135.48 | 8.40 | 24 | 0 | 24 |
0.062–0.125 | 5.81 | 1.44 | 67.74 | 16.80 | ~ 20 | ~ 5 | ~ 15 |
0.25 | 1.44 | 0.18 | 16.80 | 2.10 | ~ 5 | 0 | ~ 5 |
 | Dosage 2 × 500 mg Cmaxb = 2.85 AUC24 = 41.72 | ||||||
 | Cmax/MIC90 | Cmax/MPC90 | AUC24/MIC90 | AUC24/MPC90 | T > MIC90 | T > MPC90 | TMSW |
0.016 | 178.13 | 22.80 | 2607.50 | 333.76 | 24 | 24 | 0 |
0.031 | 91.94 | 5.70 | 1345.81 | 83.44 | 24 | ~ 20 | ~ 4 |
0.062–0.125 | 45.97 | 11.40 | 672.90 | 166.88 | 24 | ~ 22 | ~ 2 |
0.25 | 11.40 | 1.43 | 166.88 | 20.86 | ~ 22 | ~ 5 | ~ 17 |