Univariable model | Multivariable model | ||||||||
---|---|---|---|---|---|---|---|---|---|
No. of samples N = 1061 | Lactobacillus iners-dominated microbiota Univariable ORa (95% CI) | Diverse Lactobacilli Univariable ORa (95% CI) | Diverse anaerobes Univariable ORa (95% CI) | P-value | Lactobacillus iners-dominated microbiota Multivariable ORa (95% CI) | Diverse Lactobacilli Multivariable ORa (95% CI) | Diverse anaerobes Multivariable ORa (95% CI) | P-value | |
Study Cycle | 0.321 | 0.376 | |||||||
First cycle (no douche) | 207 | Ref | Ref | Ref | Ref | Ref | Ref | ||
Second cycle (douching) | 650 | 1.0 (0.7–1.5) | 0.8 (0.5–1.3) | 1.4 (0.9–2.1) | 1.0 (0.7–1.5) | 0.8 (0.5–1.4) | 1.4 (0.9–2.1) | ||
Third cycle (wash-out) | 204 | 1.0 (0.6–1.7) | 0.6 (0.2–1.7) | 1.5 (0.8–2.8) | 1.0 (0.6–1.8) | 0.6 (0.2–1.8) | 1.7 (0.9–3.1) | ||
Vaginal intercourse on day of sampling | 155 | 1.1 (0.6–2.0) | 0.9 (0.6–1.3) | 1.0 (0.4–2.4) | 0.814 | ||||
Menses on day of sampling | 208 | 1.8 (1.1–3.2) | 2.2 (1.1–4.4) | 1.7 (1.0–2.8) | 0.025 | 1.9 (1.1–3.2) | 2.2 (1.0–4.5) | 1.7 (1.0–2.9) | 0.025 |
Combined oral contraceptive use | 600 | 0.9 (0.2–5.2) | 0.9 (0.2–3.2) | 0.9 (0.1–5.5) | 0.997 | ||||
Interaction menses and douching | 0.099 | ||||||||
No menses | 601 | Ref | Ref | Ref | |||||
Menses, no douching | 376 | 2.0 (1.2–3.2) | 2.0 (0.9–4.2) | 1.5 (0.9–2.4) | |||||
Menses and douching | 84 | 2.1 (1.0–4.5) | 3.0 (1.0–9.4) | 2.6 (1.0–6.5) |