Table 1 The Characteristic of antibiotic resistance of H. pylori isolates in Zhuanghe
Characteristic | N | MNZ | CAM | LVX | AMX | TCN | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
OR(95%CI) | P value | OR(95%CI) | P value | OR(95%CI) | P value | OR(95%CI) | P value | OR(95%CI) | P value | ||
Age | |||||||||||
 ≤ 60 vs > 60 | 17 vs 83 | 0.420 (0.088–1.996) | 0.275 | 0.581 (0.198–1.705) | 0.323 | 1.160 (0.407–3.305) | 0.780 | 1.778 (0.207–15.236) | 0.6 | 0.824 (0.205–3.306) | 0.784 |
Gender | |||||||||||
 Female vs male | 46 vs 54 | 1.553 (0.600–4.020) | 0.364 | 4.457 (1.694–11.724) | 0.002 | 1.571 (0.709–3.483) | 0.266 | 1.745 (0.410–7.422) | 0.451 | 2.619 (0.770–8.903) | 0.123 |
Clinical outcome | |||||||||||
 GEU vs NGEU | 32 vs 63 | 1.006 (0.318–3.182) | 0.992 | 0.857 (0.325–2.261) | 0.756 | 0.613 (0.242–1.553) | 0.302 | 1.180 (0.252–5.537) | 0.834 | 1.886 (0.504–7.056) | 0.346 |
 GA vs GS | 36 vs 20 | 4.356 (0.854–22.223) | 0.077 | 0.258 (0.058–1.138) | 0.073 | 0.608 (0.202–1.832) | 0.377 | 0.301 (0.032–2.808) | 0.292 | 1.567 (0.342–7.180) | 0.563 |
 GEU vs GS | 32 vs 20 | 1.683 (0.496–5.709) | 0.403 | 0.632 (0.201–1.982) | 0.431 | 1.694 (0.586–4.898) | 0.33 | 0.534 (0.101–2.816) | 0.46 | 0.74 (0.162–3.417) | 0.704 |
 GEU vs GA | 32 vs 36 | 0.463 (0.063–3.395) | 0.449 | 3.182 (0.563–17.972) | 0.19 | 2.197 (0.628–7.691) | 0.218 | 0.966 (0.074–12.669) | 0.979 | 0.214 (0.034–1.368) | 0.103 |
Year | |||||||||||
 1998 to 2017 | 100 | 1.276 (0.638–2.551) | 0.491 | 1.543 (0.823–2.892) | 0.176 | 2.089 (1.142–3.821) | 0.017 | 5.035 (1.327–19.105) | 0.018 | 1.161 (0.540–2.499) | 0.702 |
Virulence factors | |||||||||||
 cagA- vs cagA+ | 13 vs 87 | 1.509 (0.409–5.561) | 0.537 | 2.192 (0.427–11.235) | 0.347 | 5.133 (1.297–20.319) | 0.02 | 0 | 0.999 | 0 | 0.999 |
 babA2- vs babA2+ | 18 vs 82 | 1.374 (0.423–4.456) | 0.597 | 0.822 (0.257–2.627) | 0.741 | 0.789 (0.276–2.303) | 0.676 | 0.854 (0.158–4.634) | 0.855 | 1.606 (0.316–8.159) | 0.568 |
 hrgA- vs hrgA+ | 43 vs 57 | 0.518 (0.188–1.431) | 0.205 | 0.419 (0.166–1.059) | 0.066 | 0.708 (0.315–1.591) | 0.403 | 1.839 (0.458–7.385) | 0.391 | 1.749 (0.569–5.376) | 0.329 |
 slyD- vs slyD+ | 54 vs 46 | 0.519 (0.196–1.376) | 0.187 | 0.585 (0.233–1.470) | 0.254 | 0.334 (0.146–0.764) | 0.009 | 0.144 (0.017–1.205) | 0.074 | 0.883 (0.282–2.765) | 0.831 |
 opiA- vs opiA+ | 33 vs 67 | 0.435 (0.141–1.340) | 0.147 | 1.163 (0.424–3.193) | 0.769 | 0.501 (0.203–1.236) | 0.133 | 0.404 (0.100–1.632) | 0.203 | 0.557 (0.179–1.731) | 0.312 |
 vacAi1- vs vacAi1+ | 36 vs 64 | 0.490 (0.161–1.494) | 0.21 | 0.448 (0.174–1.154) | 0.096 | 0.891 (0.380–2.092) | 0.791 | 0.427 (0.106–1.720) | 0.231 | 0.589 (0.190–1.824) | 0.359 |
 vacAs1m1m2 vs vacAs1m1/m2 | 42 vs 40 | 0.287 (0.096–0.863) | 0.026 | 0.763 (0.287–2.027) | 0.588 | 0.749 (0.311–1.804) | 0.52 | 0.434 (0.078–2.420) | 0.341 | 0.758 (0.215–2.667) | 0.666 |
 iceA-- vs iceA−+ | 18 vs 21 | 0.505 (0.071–3.612) | 0.496 | 1.476 (0.369–5.902) | 0.582 | 0.572 (0.135–2.415) | 0.447 | 0.489 (0.090–2.649) | 0.406 | 1.096 (0.222–5.418) | 0.91 |
 iceA-- vs iceA++ | 18 vs 61 | 0.317 (0.065–1.557) | 0.157 | 0.310 (0.094–1.020) | 0.054 | 0.428 (0.134–1.367) | 0.152 | 0.051 (0.005–0.481) | 0.009 | 0.450 (0.106–1.900) | 0.277 |
 iceA− + vs iceA++ | 21 vs 61 | 0.474 (0.122–1.847) | 0.282 | 0.234 (0.071–0.775) | 0.017 | 0.812 (0.294–2.240) | 0.688 | 0.101 (0.009–1.086) | 0.059 | 0.388 (0.099–1.527) | 0.176 |