Table 2 Data of diagnostic accuracy of studies included in the meta-analysis for rifampicin resistance tuberculosis detection
From: Xpert MTB/RIF assay for the diagnosis of rifampicin resistance in different regions: a meta-analysis
Study | First author [ref.] | Year | Total samples n (included n) | True positive | False positive | False negative | True negative | Specimen type |
|---|---|---|---|---|---|---|---|---|
Study | Al-Ateah SM [15] | 2012 | 234 (59) | 2 | 0 | 0 | 57 | Respiratory and non-respiratory specimens |
1 | Antonenka U [16] | 2013 | 121 (50) | 2 | 0 | 0 | 48 | Respiratory specimens |
2 | Balcells ME [17] | 2012 | 160 (12) | 0 | 2 | 0 | 10 | Sputum |
3 | Barmankulova A [18] | 2015 | 300 (191) | 91 | 8 | 3 | 89 | Sputum |
4 | Barnard M [19] | 2012 | 282 (36) | 3 | 0 | 0 | 33 | Sputum |
5 | Bates M [20] | 2013 | 930 (41) | 2 | 1 | 0 | 38 | Sputum, gastric lavage aspirate |
6 | Biadglegne F [21] | 2014 | 231 (32) | 2 | 1 | 0 | 29 | Lymph node aspirates |
7 | Blakemore R [22] | 2010 | 168 (79) | 37 | 0 | 0 | 42 | Sputum |
8 | Boehme CC [23] | 2010 | 1730 (720) | 200 | 10 | 5 | 505 | Sputum |
9 | Â | Peru | 341 (209) | 16 | 3 | 0 | 190 | Â |
| Â | Â | Azerbaijan | 353 (143) | 47 | 4 | 2 | 90 | Â |
| Â | Â | South Africa | 726 (183) | 18 | 0 | 1 | 164 | Â |
| Â | Â | India | 310 (185) | 119 | 3 | 2 | 61 | Â |
| Â | Boehme CC [24] | 2011 | 6648 (1060) | 236 | 14 | 14 | 796 | Sputum |
10 | Â | Peru | 1185 (185) | 22 | 1 | 1 | 161 | Â |
| Â | Â | Azerbaijan | 749 (211) | 47 | 1 | 3 | 160 | Â |
| Â | Â | South Africa | 2522 (188) | 9 | 3 | 1 | 175 | Â |
| Â | Â | Uganda | 372 (116) | 1 | 1 | 2 | 112 | Â |
| Â | Â | India | 902 (103) | 8 | 2 | 2 | 91 | Â |
| Â | Â | Philippines | 918 (257) | 149 | 6 | 5 | 97 | Â |
| Â | Bowles EC [25] | 2011 | 89 (60) | 8 | 0 | 0 | 52 | Sputum, pleural fluid, gastric fluid, bronchial washing |
11 | Carriquiry G [26] | 2012 | 131 (39) | 6 | 3 | 0 | 30 | Sputum |
12 | Cayci YT [27] | 2017 | 34 (34) | 3 | 1 | 0 | 30 | Respiratory and none-respiratory specimens |
13 | Chakravorty S [28] | 2017 | 139 (139) | 38 | 1 | 3 | 97 | Sputum |
14 | Chiang TY [29] | 2018 | 2957 (697) | 36 | 9 | 0 | 652 | Sputum |
15 | Chikaonda T [30] | 2017 | 351(200) | 2 | 1 | 0 | 185 | Sputum |
16 | Ciftçi IH [31] | 2011 | 85 (24) | 0 | 0 | 0 | 24 | Sputum, BAL, thorasynthesis fluid, urine |
17 | Deggim V [32] | 2013 | 79 (10) | 0 | 3 | 0 | 7 | Respiratory and None-respiratory |
18 | Dharan NJ [33] | 2016 | 544 (185) | 85 | 9 | 2 | 89 | Sputum |
19 | Dorman SE [34] | 2012 | 6893 (144) | 5 | 5 | 0 | 134 | Sputum |
20 | Dorman SE [35] | 2018 | 1753 (551) | 167 | 7 | 8 | 369 | Sputum |
21 | Du J [36] | 2015 | 126 (43) | 9 | 2 | 1 | 31 | Pleural biopsy specimen |
22 | Feliciano CS [37] | 2018 | 29 (29) | 12 | 3 | 4 | 10 | NR |
23 | Giang do C [38] | 2015 | 150(29) | 1 | 0 | 0 | 28 | Respiratory and non-respiratory specimens |
24 | Gu Y [39] | 2015 | 60 (24) | 6 | 0 | 0 | 18 | Pus specimens |
25 | Guenaoui K [40] | 2016 | 50 (50) | 21 | 0 | 0 | 29 | Sputum |
26 | Helb D [41] Uganda | 2010 | 64 (64) | 9 | 1 | 0 | 54 | Sputum |
27 | Hillemann D [42] | 2011 | 521 (29) | 0 | 4 | 0 | 25 | Non-respiratory specimens |
28 | Huang H [43] | 2018 | 2910 (1066) | 147 | 16 | 5 | 898 | NR |
29 | Huh HJ [44] | 2014 | 300 (98) | 6 | 1 | 1 | 90 | Respiratory specimens |
30 | Hu P [45] | 2014 | 1352 (332) | 26 | 4 | 2 | 300 | Sputum |
31 | Jin YH [46] | 2017 | 109 (48) | 4 | 4 | 1 | 39 | Pus |
32 | Kawkitinarong K [47] | 2017 | 521 (228) | 15 | 0 | 1 | 212 | Pulmonary specimens |
33 | Khalil KF [48] | 2015 | 93 (93) | 5 | 0 | 1 | 87 | BAL |
34 | Kim CH [49] | 2014 | 171 (26) | 2 | 0 | 0 | 24 | Respiratory and non-respiratory specimens |
35 | Kim CH [50] | 2015 | 383 (36) | 4 | 1 | 0 | 31 | Respiratory and Non Respiratory specimens |
36 | Kim MJ [51] | 2015 | 52 (45) | 1 | 0 | 1 | 43 | Respiratory and non-respiratory specimens |
37 | Kim SY [52] | 2012 | 71 (62) | 21 | 0 | 0 | 41 | Sputum |
38 | Kim YW [53] | 2015 | 1429 (47) | 4 | 0 | 1 | 42 | Non-respiratory specimens |
39 | Kim YW [54] | 2015 | 321 (321) | 25 | 4 | 0 | 292 | Sputum |
40 | Kokuto H [55] | 2015 | 93 (56) | 4 | 0 | 2 | 50 | Fecal specimens |
41 | Kostera J [56] | 2018 | 132 (122) | 28 | 0 | 4 | 90 | Sputum |
42 | Kurbaniyazova G [57] | 2017 | 2734 (364, solid media DST) | 120 | 20 | 12 | 212 | NR |
| Â | Â | Â | 2734 (414, liquid media DST) | 108 | 29 | 13 | 264 | NR |
43 | Kurbatova EV [58] | 2013 | 201 (99) | 57 | 1 | 5 | 36 | Sputum |
44 | Kwak N [59] | 2013 | 681 (127) | 8 | 6 | 0 | 113 | Sputum |
45 | Lawn SD [60] | 2011 | 468 (55) | 4 | 3 | 0 | 48 | Sputum |
46 | Lee HY [61] | 2013 | 132 (35) | 2 | 0 | 0 | 33 | Bronchoscopy specimens |
47 | Li Q [62] | 2016 | 1973 (449) | 47 | 16 | 6 | 380 | Sputum |
48 | Li Y [63] | 2017 | 420 (59) | 11 | 0 | 1 | 47 | Extra-pulmonary specimens |
49 | Liu X [64] | 2015 | 134 (44) | 10 | 2 | 1 | 31 | Pleural biopsy and pleural fluid specimens |
50 | Lorent N [65] | 2015 | 299 (102) | 24 | 6 | 3 | 69 | Sputum |
51 | Luetkemeyer AF [66] | 2016 | 992 (194) | 5 | 1 | 2 | 186 | Sputum |
52 | Metcalfe JZ [67] | 2016 | 352 (161) | 54 | 8 | 9 | 90 | Sputum |
53 | Mokaddas E [68] | 2015 | 452 (452) | 10 | 2 | 0 | 440 | Respiratory and non-respiratory specimens |
| Â | Â | Â | smear(+)(179) | 4 | 0 | 0 | 175 | Â |
|  |  |  | smear(−)(273) | 6 | 2 | 0 | 265 |  |
| Â | Â | Â | pulmonary(287) | 7 | 1 | 0 | 279 | Â |
| Â | Â | Â | extrapulmonary(165) | 3 | 1 | 0 | 161 | Â |
54 | Moon HW [69] | 2015 | 100 (100) | 47 | 0 | 3 | 50 | Respiratory specimens |
55 | Muñoz L [70] | 2011 | 122 (85) | 6 | 0 | 1 | 78 | Respiratory and non-respiratory specimens |
56 | Mwanza W [71] | 2018 | 1070 (24) | 13 | 3 | 0 | 8 | NR |
57 | Myneedu VP [72] | 2014 | 134 (88) | 54 | 1 | 1 | 32 | Sputum |
58 | N’guessan K [73] | 2014 | 120 (29) | 14 | 4 | 0 | 11 | Sputum |
59 | N’Guessan K [74] | 2018 | 1095 (162) | 112 | 8 | 0 | 42 | Sputum |
60 | Nikolayevskyy V [75] | 2018 | 3478 (3167) | 1212 | 77 | 86 | 1792 | Pulmonary specimens |
61 | Nicol MP [76] | 2011 | 452 (77) | 3 | 4 | 0 | 70 | Sputum |
62 | O’Grady J [77] | 2012 | 881 (96) | 13 | 2 | 3 | 78 | Sputum |
63 | Ou X [78] | 2014 | 2454 (616) | 54 | 16 | 8 | 538 | Sputum |
64 | Ozkutuk N [79] | 2014 | 2639 (133) | 1 | 1 | 0 | 131 | Respiratory and non-respiratory specimens |
65 | Pan X [80] | 2018 | 190 (62) | 2 | 2 | 0 | 58 | Sputum and BAL |
66 | Pang Y [81] | 2014 | 211 (10) | 1 | 0 | 0 | 9 | Gastric lavage aspirates |
67 | Park KS [82] | 2013 | 320 (19) | 2 | 0 | 0 | 17 | Respiratory specimens |
68 | Pimkina E [83] | 2015 | 791 (264) | 39 | 4 | 0 | 221 | Sputum |
69 | Pinyopornpanish K [84] | 2015 | 57 (43) | 0 | 0 | 3 | 40 | Sputum |
70 | Rachow A [85] | 2011 | 292 (61) | 0 | 0 | 0 | 61 | Sputum |
71 | Rahman A [86] | 2016 | 92 (92) | 85 | 6 | 0 | 1 | Sputum |
72 | Raizada N [87] | 2014 | 4600 (48) | 47 | 1 | 0 | 0 | Sputum |
73 | Reither K [88] | 2015 | 451 (25) | 0 | 0 | 0 | 25 | Sputum |
74 | Rice JP [89] | 2017 | 637 (120) | 2 | 2 | 0 | 116 | Sputum |
75 | Sharma SK [90] | 2015 | 1406 (422) | 104 | 7 | 6 | 305 | Respiratory specimens |
76 | Sharma SK [91] | 2017 | 2468 (328) | 38 | 2 | 3 | 285 | Extra-pulmonary specimens |
77 | Singh UB [92] | 2016 | 1145 (72) | 14 | 0 | 2 | 56 | Pulmonary and extra-pulmonary specimens |
78 | Soeroto AY [93] | 2019 | 339 (158) | 141 | 17 | 0 | 0 | NR |
79 | Ssengooba W [94] | 2014 | 424 (94) | 4 | 0 | 0 | 9 | Sputum |
80 | Strydom K [95] | 2015 | 120 (115) | 59 | 1 | 2 | 53 | Sputum |
81 | Tahseen S [96] | 2016 | 1984 (1533) | 85 | 17 | 15 | 1416 | Sputum |
82 | Theron G [97] | 2011 | 480 (157) | 5 | 1 | 0 | 151 | Sputum |
83 | Tsuyuguchi K [98] | 2017 | 237 (201) | 22 | 3 | 0 | 176 | Sputum |
84 | Ullah I [99] | 2017 | 266 (88) | 24 | 2 | 0 | 62 | Extra-pulmonary specimens |
85 | Vadwai V [100] | 2011 | 547 (125) | 39 | 5 | 1 | 80 | Non-respiratory specimens |
86 | van Kampen SC [101] | 2015 | 5611(1054) | 522 | 31 | 33 | 468 | Sputum |
87 | van Kampen SC [102] | 2015 | 1442 (339) | 158 | 18 | 21 | 142 | Sputum |
88 | Wang G [103] | 2017 | 1461 (538) | 145 | 0 | 3 | 390 | Pulmonary and extra-pulmonary specimens |
89 | Wang G 104] | 2019 | 229 (119) | 21 | 0 | 1 | 97 | Sputum, pleural fluid |
| Â | Â | Â | 90 | 15 | 0 | 1 | 74 | Sputum |
| Â | Â | Â | 29 | 6 | 0 | 0 | 23 | Pleural fluid |
90 | Williamson DA [105] | 2012 | 169 (14) | 7 | 6 | 0 | 1 | Respiratory; extra-pulmonary specimens, positive MGIT liquid culture vials |
91 | Yin QQ [106] | 2014 | 255 (21) | 1 | 0 | 0 | 20 | BALF |
92 | Yuan M [107] | 2016 | 328(90) | 12 | 0 | 3 | 75 | Extra-pulmonary specimens |
93 | Zar HJ [108] | 2012 | 535 (125) | 5 | 5 | 1 | 114 | Nasopharyngeal specimens, sputum |
94 | Zar HJ [109] | 2014 | 384 (18) | 0 | 0 | 0 | 18 | Sputum Nasopharyngeal aspirate specimens |
95 | Zetola NM [110] | 2014 | 370 (370) | 51 | 1 | 4 | 314 | Sputum |
97 | Zhang AM [111] | 2016 | 109 (21) | 6 | 0 | 0 | 15 | Pulmonary and extra-pulmonary specimens |