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Table 2 Data of diagnostic accuracy of studies included in the meta-analysis for rifampicin resistance tuberculosis detection

From: Xpert MTB/RIF assay for the diagnosis of rifampicin resistance in different regions: a meta-analysis

Study First author [ref.] Year Total samples n (included n) True positive False positive False negative True negative Specimen type
Study Al-Ateah SM [15] 2012 234 (59) 2 0 0 57 Respiratory and non-respiratory specimens
1 Antonenka U [16] 2013 121 (50) 2 0 0 48 Respiratory specimens
2 Balcells ME [17] 2012 160 (12) 0 2 0 10 Sputum
3 Barmankulova A [18] 2015 300 (191) 91 8 3 89 Sputum
4 Barnard M [19] 2012 282 (36) 3 0 0 33 Sputum
5 Bates M [20] 2013 930 (41) 2 1 0 38 Sputum, gastric lavage aspirate
6 Biadglegne F [21] 2014 231 (32) 2 1 0 29 Lymph node aspirates
7 Blakemore R [22] 2010 168 (79) 37 0 0 42 Sputum
8 Boehme CC [23] 2010 1730 (720) 200 10 5 505 Sputum
9   Peru 341 (209) 16 3 0 190  
   Azerbaijan 353 (143) 47 4 2 90  
   South Africa 726 (183) 18 0 1 164  
   India 310 (185) 119 3 2 61  
  Boehme CC [24] 2011 6648 (1060) 236 14 14 796 Sputum
10   Peru 1185 (185) 22 1 1 161  
   Azerbaijan 749 (211) 47 1 3 160  
   South Africa 2522 (188) 9 3 1 175  
   Uganda 372 (116) 1 1 2 112  
   India 902 (103) 8 2 2 91  
   Philippines 918 (257) 149 6 5 97  
  Bowles EC [25] 2011 89 (60) 8 0 0 52 Sputum, pleural fluid, gastric fluid, bronchial washing
11 Carriquiry G [26] 2012 131 (39) 6 3 0 30 Sputum
12 Cayci YT [27] 2017 34 (34) 3 1 0 30 Respiratory and none-respiratory specimens
13 Chakravorty S [28] 2017 139 (139) 38 1 3 97 Sputum
14 Chiang TY [29] 2018 2957 (697) 36 9 0 652 Sputum
15 Chikaonda T [30] 2017 351(200) 2 1 0 185 Sputum
16 Ciftçi IH [31] 2011 85 (24) 0 0 0 24 Sputum, BAL, thorasynthesis fluid, urine
17 Deggim V [32] 2013 79 (10) 0 3 0 7 Respiratory and None-respiratory
18 Dharan NJ [33] 2016 544 (185) 85 9 2 89 Sputum
19 Dorman SE [34] 2012 6893 (144) 5 5 0 134 Sputum
20 Dorman SE [35] 2018 1753 (551) 167 7 8 369 Sputum
21 Du J [36] 2015 126 (43) 9 2 1 31 Pleural biopsy specimen
22 Feliciano CS [37] 2018 29 (29) 12 3 4 10 NR
23 Giang do C [38] 2015 150(29) 1 0 0 28 Respiratory and non-respiratory specimens
24 Gu Y [39] 2015 60 (24) 6 0 0 18 Pus specimens
25 Guenaoui K [40] 2016 50 (50) 21 0 0 29 Sputum
26 Helb D [41] Uganda 2010 64 (64) 9 1 0 54 Sputum
27 Hillemann D [42] 2011 521 (29) 0 4 0 25 Non-respiratory specimens
28 Huang H [43] 2018 2910 (1066) 147 16 5 898 NR
29 Huh HJ [44] 2014 300 (98) 6 1 1 90 Respiratory specimens
30 Hu P [45] 2014 1352 (332) 26 4 2 300 Sputum
31 Jin YH [46] 2017 109 (48) 4 4 1 39 Pus
32 Kawkitinarong K [47] 2017 521 (228) 15 0 1 212 Pulmonary specimens
33 Khalil KF [48] 2015 93 (93) 5 0 1 87 BAL
34 Kim CH [49] 2014 171 (26) 2 0 0 24 Respiratory and non-respiratory specimens
35 Kim CH [50] 2015 383 (36) 4 1 0 31 Respiratory and Non Respiratory specimens
36 Kim MJ [51] 2015 52 (45) 1 0 1 43 Respiratory and non-respiratory specimens
37 Kim SY [52] 2012 71 (62) 21 0 0 41 Sputum
38 Kim YW [53] 2015 1429 (47) 4 0 1 42 Non-respiratory specimens
39 Kim YW [54] 2015 321 (321) 25 4 0 292 Sputum
40 Kokuto H [55] 2015 93 (56) 4 0 2 50 Fecal specimens
41 Kostera J [56] 2018 132 (122) 28 0 4 90 Sputum
42 Kurbaniyazova G [57] 2017 2734 (364, solid media DST) 120 20 12 212 NR
    2734 (414, liquid media DST) 108 29 13 264 NR
43 Kurbatova EV [58] 2013 201 (99) 57 1 5 36 Sputum
44 Kwak N [59] 2013 681 (127) 8 6 0 113 Sputum
45 Lawn SD [60] 2011 468 (55) 4 3 0 48 Sputum
46 Lee HY [61] 2013 132 (35) 2 0 0 33 Bronchoscopy specimens
47 Li Q [62] 2016 1973 (449) 47 16 6 380 Sputum
48 Li Y [63] 2017 420 (59) 11 0 1 47 Extra-pulmonary specimens
49 Liu X [64] 2015 134 (44) 10 2 1 31 Pleural biopsy and pleural fluid specimens
50 Lorent N [65] 2015 299 (102) 24 6 3 69 Sputum
51 Luetkemeyer AF [66] 2016 992 (194) 5 1 2 186 Sputum
52 Metcalfe JZ [67] 2016 352 (161) 54 8 9 90 Sputum
53 Mokaddas E [68] 2015 452 (452) 10 2 0 440 Respiratory and non-respiratory specimens
    smear(+)(179) 4 0 0 175  
    smear(−)(273) 6 2 0 265  
    pulmonary(287) 7 1 0 279  
    extrapulmonary(165) 3 1 0 161  
54 Moon HW [69] 2015 100 (100) 47 0 3 50 Respiratory specimens
55 Muñoz L [70] 2011 122 (85) 6 0 1 78 Respiratory and non-respiratory specimens
56 Mwanza W [71] 2018 1070 (24) 13 3 0 8 NR
57 Myneedu VP [72] 2014 134 (88) 54 1 1 32 Sputum
58 N’guessan K [73] 2014 120 (29) 14 4 0 11 Sputum
59 N’Guessan K [74] 2018 1095 (162) 112 8 0 42 Sputum
60 Nikolayevskyy V [75] 2018 3478 (3167) 1212 77 86 1792 Pulmonary specimens
61 Nicol MP [76] 2011 452 (77) 3 4 0 70 Sputum
62 O’Grady J [77] 2012 881 (96) 13 2 3 78 Sputum
63 Ou X [78] 2014 2454 (616) 54 16 8 538 Sputum
64 Ozkutuk N [79] 2014 2639 (133) 1 1 0 131 Respiratory and non-respiratory specimens
65 Pan X [80] 2018 190 (62) 2 2 0 58 Sputum and BAL
66 Pang Y [81] 2014 211 (10) 1 0 0 9 Gastric lavage aspirates
67 Park KS [82] 2013 320 (19) 2 0 0 17 Respiratory specimens
68 Pimkina E [83] 2015 791 (264) 39 4 0 221 Sputum
69 Pinyopornpanish K [84] 2015 57 (43) 0 0 3 40 Sputum
70 Rachow A [85] 2011 292 (61) 0 0 0 61 Sputum
71 Rahman A [86] 2016 92 (92) 85 6 0 1 Sputum
72 Raizada N [87] 2014 4600 (48) 47 1 0 0 Sputum
73 Reither K [88] 2015 451 (25) 0 0 0 25 Sputum
74 Rice JP [89] 2017 637 (120) 2 2 0 116 Sputum
75 Sharma SK [90] 2015 1406 (422) 104 7 6 305 Respiratory specimens
76 Sharma SK [91] 2017 2468 (328) 38 2 3 285 Extra-pulmonary specimens
77 Singh UB [92] 2016 1145 (72) 14 0 2 56 Pulmonary and extra-pulmonary specimens
78 Soeroto AY [93] 2019 339 (158) 141 17 0 0 NR
79 Ssengooba W [94] 2014 424 (94) 4 0 0 9 Sputum
80 Strydom K [95] 2015 120 (115) 59 1 2 53 Sputum
81 Tahseen S [96] 2016 1984 (1533) 85 17 15 1416 Sputum
82 Theron G [97] 2011 480 (157) 5 1 0 151 Sputum
83 Tsuyuguchi K [98] 2017 237 (201) 22 3 0 176 Sputum
84 Ullah I [99] 2017 266 (88) 24 2 0 62 Extra-pulmonary specimens
85 Vadwai V [100] 2011 547 (125) 39 5 1 80 Non-respiratory specimens
86 van Kampen SC [101] 2015 5611(1054) 522 31 33 468 Sputum
87 van Kampen SC [102] 2015 1442 (339) 158 18 21 142 Sputum
88 Wang G [103] 2017 1461 (538) 145 0 3 390 Pulmonary and extra-pulmonary specimens
89 Wang G 104] 2019 229 (119) 21 0 1 97 Sputum, pleural fluid
    90 15 0 1 74 Sputum
    29 6 0 0 23 Pleural fluid
90 Williamson DA [105] 2012 169 (14) 7 6 0 1 Respiratory; extra-pulmonary specimens, positive MGIT liquid culture vials
91 Yin QQ [106] 2014 255 (21) 1 0 0 20 BALF
92 Yuan M [107] 2016 328(90) 12 0 3 75 Extra-pulmonary specimens
93 Zar HJ [108] 2012 535 (125) 5 5 1 114 Nasopharyngeal specimens, sputum
94 Zar HJ [109] 2014 384 (18) 0 0 0 18 Sputum Nasopharyngeal aspirate specimens
95 Zetola NM [110] 2014 370 (370) 51 1 4 314 Sputum
97 Zhang AM [111] 2016 109 (21) 6 0 0 15 Pulmonary and extra-pulmonary specimens
  1. IQR Interquartile range, TA Tracheal aspirate, BA Bronchial aspirate, BAL Bronchoalveolar lavage, LN Lymph node, CSF Cerebrospinal fluid, EPTB Extra-pulmonary tuberculosis, CCRS Composite clinical reference standard, FNA Fine needle aspirate; DST: drug-susceptibility testing