Table 5 Genetic determinants for cephalosporins and quinolones resistance in Shigella strains showing concurrently decreased susceptibility to these antibiotics
Strains | Resistance Phenotypes | QRDR mutation | PMQR | ESBLs | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
CAZ | CRO | CFP | CFZ | LEV | NOR | gyrA | parC | |||
LJ-07-011 | S | R | R | R | R | R | Ser83Leu, His211Tyr | Ser80Ile | qnrS | blaOXA,blaTEM |
LJ-07-037 | S | R | R | R | R | R | Ser83Leu, His211Tyr | Ser80Ile | qnrS, acc(6′)-Ib-cr | bla CTX-M-3 |
LJ-07-042 | S | R | R | R | R | R | Ser83Leu, His211Tyr | Ser80Ile | qnrS | blaOXA,blaTEM,blaCMY |
LJ-12-049 | I | R | R | R | S | R | Ser83Leu, His211Tyr | Ser80Ile | ||
LJ-13-009 | I | R | R | R | I | R | Ser83Leu, His211Tyr | Ser80Ile | qnrS | blaCTX-M-55, blaOXA, blaTEM |
LJ-13-010 | I | R | R | R | I | R | Ser83Leu, His211Tyr | Ser80Ile | qnrS | blaCTX-M-55, blaOXA, blaTEM |
LJ-13-011 | S | R | R | R | I | R | Ser83Leu, His211Tyr | Ser80Ile | qnrS, acc(6′)-Ib-cr | blaCTX-M-14,blaTEM |
LJ-13-040 | I | R | R | R | I | R | Ser83Leu, His211Tyr | Ser80Ile | blaCTX-M-15,blaOXA,blaSHV | |
LJ-14-015 | I | R | R | R | I | R | Ser83Leu, His211Tyr | Ser80Ile | qnrB | bla CTX-M-55, bla OXA, bla TEM |
ZD-13-001 | S | R | I | R | S | R | Ser83Leu, His211Tyr | Ser80Ile | qnrS | bla TEM |
ZD-13-022 | S | R | R | R | S | R | Ser83Leu, His211Tyr | Ser80Ile | blaCTX-M-14,blaTEM | |
ZD-14-029 | S | R | I | R | I | R | Ser83Leu, His211Tyr | Ser80Ile | qnrS | blaCTX-M-14,blaTEM,blaOXA |
ZD-15-020 | S | R | R | R | S | R | Ser83Leu, sp87Gly, His211Tyr | Ser80Ile | qnrS | blaCTX-M-14,blaTEM |
ZD-16-027 | I | R | R | R | S | R | Ser83Leu, His211Tyr | Ser80Ile | qnrS | blaCTX-M-55,blaTEM |