Skip to main content

Table 5 Fitness cost of investigated spontaneous mutation

From: Rifampin resistance and its fitness cost in Riemerella anatipestifer

Mutant

No.of generation

Cost per

D0–1.0OD

Relative fitness

Strain

gS

gR

generation

(gR/gS)

Q478R

8.76

7.88

0.08 ± 0.05

−0.08 ± 0.05

0.90 ± 0.06

Q478K

8.59

8.36

0.02 ± 0.03

−0.02 ± 0.04

0.97 ± 0.05

D481V

8.35

8.27

0.01 ± 0.05

−0.01 ± 0.05

1.00 ± 0.07

D481Y

10.51

9.50

0.07 ± 0.01

−0.07 ± 0.01

0.90 ± 0.02

S487Y

8.84

8.00

0.07 ± 0.05

−0.07 ± 0.05

0.91 ± 0.06

S487F

8.02

7.67

0.03 ± 0.02

−0.03 ± 0.02

0.96 ± 0.03

H491Y

8.93

8.51

0.03 ± 0.05

−0.04 ± 0.05

0.95 ± 0.07

H491D

9.08

5.47

0.35 ± 0.04

−0.44 ± 0.07

0.60 ± 0.02

H491R

8.35

7.32

0.09 ± 0.02

−0.10 ± 0.02

0.88 ± 0.03

R494K

10.00

9.13

0.07 ± 0.06

−0.07 ± 0.07

0.91 ± 0.07

S496 L

8.76

8.39

0.04 ± 0.04

−0.04 ± 0.04

0.95 ± 0.06

I537N

8.59

7.13

0.13 ± 0.04

−0.14 ± 0.04

0.83 ± 0.04

S539F

8.76

7.92

0.08 ± 0.01

−0.09 ± 0.14

0.91 ± 0.15

485::TAA

9.22

5.83

0.35 ± 0.05

−0.43 ± 0.08

0.63 ± 0.06

S496 L+  535::G

9.71

8.01

0.14 ± 0.07

−0.15 ± 0.08

0.83 ± 0.08