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Table 5 Non-susceptibility rates of S. aureus in pediatric population in China [N (%)]

From: Accessory gene regulator (agr) dysfunction was unusual in Staphylococcus aureus isolated from Chinese children

 

No. of isolates

PEN

OXA

ERY

CLI

TET

GEN

CHL

RIF

CIP

SXT

MDR

MRSA

211

207 (98.10)

176 (83.41)

208 (98.58)

181 (85.78)

103 (48.82)

38 (18.01)

121 (57.35)

22 (10.43)

65 (30.81)

5 (2.37)

169 (80.09)

 Dysfunctional agr

8

8 (100.0)

7 (87.50)

8 (100.0)

7 (87.50)

6 (75.00)

6 (75.00)

3 (37.50)

1 (12.50)

7 (87.50)

3 (37.50)

7 (87.50)

 Functional agr

203

199 (98.03)

169 (83.25)

200 (98.52)

174 (85.71)

97 (47.78)

32 (15.76)

118 (58.13)

21 (10.34)

58 (28.57)

2 (0.99)

162 (79.80)

 aP-value

 

1.0000

1.0000

1.0000

1.0000

0.1627

0.0005

0.2904

0.5921

0.0013

0.0003

1.0000

MSSA

58

54 (93.10)

0

58 (100.00

19 (32.76)

11 (18.97)

12 (20.69)

33 (56.90)

0

11 (18.97)

0

43 (74.14)

Total

269

261 (97.03)

176 (65.43)

266 (98.89)

200 (74.35)

114 (42.38)

50 (18.59)

154 (57.25)

22 (8.18)

76 (28.25)

5 (1.86)

212 (78.81)

bP-value

 

0.0688

< 0.0001

1.0000

< 0.0001

< 0.0001

0.7033

1.0000

0.0057

0.0990

0.5883

0.3648

  1. All isolates were susceptible to vancomycin and linezolid, and hence, not listed in the table
  2. PEN Penicillin, OXA oxacillin, ERY Erythromycin, CLI Clindamycin, TET Tetracycline, GEN Gentamicin, CHL Chloramphenicol, CIP Ciprofloxacin, RIF Rifampin, SXT Trimethoprim-sulfamethoxazole
  3. MDR multi-drug resistance, MDR-MRSA resistant to ≥3 classes of non-β-lactam antimicrobials, MDR-MSSA resistant to ≥3 classes of antibiotics including β-lactam antibiotics
  4. aComparison between agr dysfunctional and agr functional isolates among MRSA
  5. bComparison between MRSA and MSSA isolates