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Table 3 Selected KEGG pathways (KEGG orthology level 3) in colonic samples being differently enriched in CON- and TGS-fed pigs

From: Functional adaptations in the cecal and colonic metagenomes associated with the consumption of transglycosylated starch in a pig model

KEGG pathway

Meana

log2 fold change

SEb

p value

q value

00633 Nitrotoluene degradation [PATH:ko00633]

661

2.575

0.351

< 0.001

< 0.001

00983 Drug metabolism - other enzymes [PATH:ko00983]

818

1.910

0.160

< 0.001

< 0.001

00531 Glycosaminoglycan degradation [PATH:ko00531]

397

1.868

0.276

< 0.001

< 0.001

02060 Phosphotransferase system (PTS) [PATH:ko02060]

9299

1.739

0.228

< 0.001

< 0.001

00940 Phenylpropanoid biosynthesis [PATH:ko00940]

8963

1.542

0.148

< 0.001

< 0.001

00130 Ubiquinone and other terpenoid-quinone biosynthesis [PATH:ko00130]

3636

1.510

0.145

< 0.001

< 0.001

00710 Carbon fixation in photosynthetic organisms [PATH:ko00710]

202

1.422

0.373

< 0.001

< 0.001

00590 Arachidonic acid metabolism [PATH:ko00590]

922

1.336

0.321

< 0.001

< 0.001

00910 Nitrogen metabolism [PATH:ko00910]

1675

1.152

0.262

< 0.001

< 0.001

00740 Riboflavin metabolism [PATH:ko00740]

4762

1.040

0.199

< 0.001

< 0.001

00511 Other glycan degradation [PATH:ko00511]

2787

1.016

0.174

< 0.001

< 0.001

00051 Fructose and mannose metabolism [PATH:ko00051]

16,391

0.746

0.089

< 0.001

< 0.001

04141 Protein processing in endoplasmic reticulum [PATH:ko04141]

784

0.728

0.143

< 0.001

< 0.001

00052 Galactose metabolism [PATH:ko00052]

21,809

0.713

0.091

< 0.001

< 0.001

04142 Lysosome [PATH:ko04142]

2980

0.683

0.153

< 0.001

< 0.001

00860 Porphyrin and chlorophyll metabolism [PATH:ko00860]

10,480

0.647

0.102

< 0.001

< 0.001

00040 Pentose and glucuronate interconversions [PATH:ko00040]

13,379

0.593

0.101

< 0.001

< 0.001

00750 Vitamin B6 metabolism [PATH:ko00750]

3823

0.559

0.127

< 0.001

< 0.001

00281 Geraniol degradation [PATH:ko00281]

614

0.549

0.144

< 0.001

< 0.001

00020 Citrate cycle (TCA cycle) [PATH:ko00020]

16,331

0.533

0.089

< 0.001

< 0.001

00730 Thiamine metabolism [PATH:ko00730]

8664

0.522

0.097

< 0.001

< 0.001

00790 Folate biosynthesis [PATH:ko00790]

3122

0.507

0.124

< 0.001

< 0.001

00400 Phenylalanine tyrosine and tryptophan biosynthesis [PATH:ko00400]

17,524

0.386

0.094

< 0.001

< 0.001

00330 Arginine and proline metabolism [PATH:ko00330]

27,975

0.296

0.058

< 0.001

< 0.001

00340 Histidine metabolism [PATH:ko00340]

15,847

0.252

0.048

< 0.001

< 0.001

03018 RNA degradation [PATH:ko03018]

31,058

−0.206

0.052

< 0.001

< 0.001

03010 Ribosome [PATH:ko03010]

59,767

−0.279

0.066

< 0.001

< 0.001

00010 Glycolysis / Gluconeogenesis [PATH:ko00010]

25,589

−0.307

0.043

< 0.001

< 0.001

00970 Aminoacyl-tRNA biosynthesis [PATH:ko00970]

96,501

−0.377

0.066

< 0.001

< 0.001

03070 Bacterial secretion system [PATH:ko03070]

26,474

−0.429

0.079

< 0.001

< 0.001

03020 RNA polymerase [PATH:ko03020]

30,568

−0.656

0.072

< 0.001

< 0.001

00310 Lysine degradation [PATH:ko00310]

788

−0.991

0.220

< 0.001

< 0.001

04151 PI3K-Akt signaling pathway [PATH:ko04151]

4509

−1.058

0.083

< 0.001

< 0.001

00360 Phenylalanine metabolism [PATH:ko00360]

2719

−1.103

0.149

< 0.001

< 0.001

04122 Sulfur relay system [PATH:ko04122]

7389

−1.137

0.086

< 0.001

< 0.001

00350 Tyrosine metabolism [PATH:ko00350]

3212

− 1.404

0.164

< 0.001

< 0.001

00785 Lipoic acid metabolism [PATH:ko00785]

187

−1.562

0.244

< 0.001

< 0.001

00380 Tryptophan metabolism [PATH:ko00380]

304

−1.595

0.181

< 0.001

< 0.001

00791 Atrazine degradation [PATH:ko00791]

196

−2.087

0.374

< 0.001

< 0.001

03040 Spliceosome [PATH:ko03040]

203

−2.108

0.292

< 0.001

< 0.001

00660 C5-Branched dibasic acid metabolism [PATH:ko00660]

142

−4.390

0.563

< 0.001

< 0.001

00540 Lipopolysaccharide biosynthesis [PATH:ko00540]

9910

0.965

0.261

0.000

0.001

02010 ABC transporters [PATH:ko02010]

65,587

−0.243

0.070

0.001

0.001

00500 Starch and sucrose metabolism [PATH:ko00500]

22,311

−0.256

0.073

< 0.001

0.001

03420 Nucleotide excision repair [PATH:ko03420]

23,037

−0.270

0.078

0.001

0.001

00680 Methane metabolism [PATH:ko00680]

5869

−0.359

0.099

< 0.001

0.001

00071 Fatty acid metabolism [PATH:ko00071]

136

−1.551

0.426

< 0.001

0.001

00230 Purine metabolism [PATH:ko00230]

49,811

−0.134

0.040

0.001

0.002

00640 Propanoate metabolism [PATH:ko00640]

530

−0.546

0.165

0.001

0.002

00510 N-Glycan biosynthesis [PATH:ko00510]

785

0.460

0.148

0.002

0.004

00900 Terpenoid backbone biosynthesis [PATH:ko00900]

13,580

0.143

0.046

0.002

0.004

00620 Pyruvate metabolism [PATH:ko00620]

22,435

−0.192

0.063

0.002

0.005

03060 Protein export [PATH:ko03060]

1837

0.318

0.107

0.003

0.006

00250 Alanine aspartate and glutamate metabolism [PATH:ko00250]

69,446

0.133

0.045

0.003

0.007

00260 Glycine serine and threonine metabolism [PATH:ko00260]

42,580

−0.110

0.039

0.005

0.009

03013 RNA transport [PATH:ko03013]

1374

−0.285

0.111

0.010

0.020

00550 Peptidoglycan biosynthesis [PATH:ko00550]

17,416

−0.145

0.059

0.014

0.027

01040 Biosynthesis of unsaturated fatty acids [PATH:ko01040]

108

−1.247

0.512

0.015

0.028

00053 Ascorbate and aldarate metabolism [PATH:ko00053]

466

0.595

0.250

0.017

0.031

03030 DNA replication [PATH:ko03030]

31,056

−0.233

0.098

0.018

0.031

00300 Lysine biosynthesis [PATH:ko00300]

23,272

0.118

0.050

0.019

0.033

00520 Amino sugar and nucleotide sugar metabolism [PATH:ko00520]

20,592

0.107

0.046

0.020

0.035

00362 Benzoate degradation [PATH:ko00362]

479

0.797

0.368

0.030

0.051

03440 Homologous recombination [PATH:ko03440]

20,390

−0.127

0.060

0.035

0.058

00440 Phosphonate and phosphinate metabolism [PATH:ko00440]

788

0.628

0.307

0.041

0.065

00561 Glycerolipid metabolism [PATH:ko00561]

5347

0.269

0.135

0.046

0.071

00290 Valine leucine and isoleucine biosynthesis [PATH:ko00290]

23,041

0.159

0.080

0.046

0.071

00270 Cysteine and methionine metabolism [PATH:ko00270]

33,967

0.118

0.061

0.055

0.083

02030 Bacterial chemotaxis [PATH:ko02030]

8408

0.622

0.327

0.057

0.085

00030 Pentose phosphate pathway [PATH:ko00030]

14,947

−0.111

0.059

0.062

0.090

  1. False discovery rate (Benjamini-Hochberg) corrected p value
  2. aNormalized reads (hit counts). Only the most abundant KEGG pathways (> 0.01% of all reads) that were altered by the dietary starch source are presented (n = 8 per diet)
  3. bStandard error of the log2fold change