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Table 4 Mutation sites detected in fusA in two methicillin-resistant Staphylococcus aureus (MRSA), 18 methicillin-resistant S. pseudintermedius (MRSP) and 4 methicillin-sensitive S. pseudintermedius (MSSP) isolates

From: Genetic resistance determinants to fusidic acid and chlorhexidine in variably susceptible staphylococci from dogs

Amino acid substitution Nucleotide substitution No. of isolates Fusidic acid MIC (mg/L)
L461K TTA - > AAA 2 (SEUK MRSA) 384a
I461K ATT - > AAA 1 (NUK MSSP) >  64
V90I / A376V / I461T GTA - > ATA / GCA - > GTA / ATT - > ACT 1 (NUK MSSP) >  64
20 (n = 12 FA-R Finland MRSP; n = 1 Finland MRSP, n = 2 NUK MSSP, n = 4 NUK MRSP, n = 1 SEUK MRSP) 64
  1. MIC minimum inhibitory concentration, SEUK South-East U.K, NUK North U.K.
  2. aMIC determined as part of previous study (reference [52])