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Table 2 Minimum inhibitory concentrations (MICs) of chlorhexidine determined by agar dilution, and presence of resistance determinants, for canine-derived Staphylococcus pseudintermedius and S. aureus isolates (n = 538) from Finland, the U.S.A., North U.K. (NUK), South-East U.K. (SEUK) and Germany

From: Genetic resistance determinants to fusidic acid and chlorhexidine in variably susceptible staphylococci from dogs

Country Bacterial Type n Chlorhexidine MIC (mg/L) MIC50 MIC90
0.125 0.25 0.5 1 2 4 8 16 mg/L mg/L
Finland MRSP 49 0 1 35 12 0 1 0 0 0.5 1
MSSP 50 0 0 38 12 0 0 0 0 0.5 1
U.S.A. MRSP 50 0 0 35 n = 2 smr 15 n = 1 smr 0 0 0 0 0.5 1
MSSP 51 0 0 45 n = 1 smr 4 1 1 0 0 0.5 1
NUKb MRSP 49 0 0 0 16 25 8 0 0 2 4
MSSP 50 0 0 0 36 14 n = 1 qacA/B 0 0 0 1 2
SEUKa MRSP 47 0 0 0 21 23 2 1 0 2 2
MSSP 44 0 0 1 22 17 2 2 0 1 2
MRSA 50 0 0 0 0 0 49 1 0 4 4
MSSA 50 0 0 1 22 22 5 n = 1 qacA/B n = 1 smr 0 0 2 2
Germanya MRSP 24 0 0 9 4 11 0 0 0 1 2
MSSP 24 0 0 11 13 0 0 0 0 1 1
  1. MRSP methicillin-resistant Staphylococcus pseudintermedius, MSSP methicillin-sensitive S. pseudintermedius, NUK North U.K., SEUK South-East U.K, MRSA methicillin-resistant S. aureus, MSSA methicillin-susceptible S. aureus.
  2. aMICs determined as part of previous study by the authors (reference [52])
  3. bMICs determined as part of previous study by the authors (reference [45])